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γ-Linolenic Acid methyl ester

Catalog No. T21504 CAS 16326-32-2

Synonyms: Methyl gamma-linolenate

γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.

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γ-Linolenic Acid methyl ester Chemical Structure

γ-Linolenic Acid methyl ester, CAS 16326-32-2

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Description	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.
Targets&IC50	LTB4:1 μM (ki; GLA)
In vitro	γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM
In vivo	In an in-vivo model of LTB4-induced bronchoconstriction, γ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 53% inhibition, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for reported anti-inflammatory activities.

Synonyms	Methyl gamma-linolenate
Molecular Weight	292.46
Formula	C19H32O2
CAS No.	16326-32-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

dimethyl formamide: 100mg/ml (341.88 mM)

DMSO: 100mg/ml (341.88 mM)

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Natural Product Library Natural Product Library for HTS Bioactive Compound Library Selected Plant-Sourced Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Keywords

γ-Linolenic Acid methyl ester 16326-32-2 Immunology/Inflammation LTR γ Linolenic Acid methyl ester r-Linolenic Acid methyl ester gamma-Linolenic Acid methyl ester Methyl gamma-linolenate γLinolenic Acid methyl ester inhibitor inhibit

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