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Chelidonic acid

Catalog No. T5558 CAS 99-32-1

Synonyms: Jervaic acid, Jerva acid, γ-Pyrone-2,6-dicarboxylic acid

Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.

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Chelidonic acid, CAS 99-32-1

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50 mg	In stock	$ 33.00
100 mg	In stock	$ 48.00

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Purity: 98%

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Description	Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.
Targets&IC50	Glutamate decarboxylase (GAD):1.2 μM (Ki)
In vivo	Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice[3]. Chelidonic acid may attenuate allergic reactions by inhibiting caspase-1 activity.
Animal Research	female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge.
Source	Natural Products > Papaveraceae > Chelidonium

Synonyms	Jervaic acid, Jerva acid, γ-Pyrone-2,6-dicarboxylic acid
Molecular Weight	184.1
Formula	C7H4O6
CAS No.	99-32-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/mL (21.72 mM)

References and Literature

1. Singh D K , Gulati K , Ray A . Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats[J]. International Immunopharmacology, 2016, 40:229-234.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Traditional Chinese Medicine Monomer Library Anti-Pancreatic Cancer Compound Library Pyroptosis Compound Library Anti-Tumor Natural Product Library Anti-Ovarian Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Liver Cancer Compound Library Chinese Pharmacopoeia Natural Product Library Bioactive Compound Library

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Keywords

Chelidonic acid 99-32-1 Apoptosis NF-Κb Proteases/Proteasome Caspase NF-κB gamma-Pyrone-2,6-dicarboxylic acid Jervaic acid Jerva acid Inhibitor inhibit Nuclear factor-κB Nuclear factor-kappaB r-Pyrone-2,6-dicarboxylic acid γ-Pyrone-2,6-dicarboxylic acid inhibitor

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