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CB1-IN-1

Catalog No. T5996   CAS 1429239-98-4
Synonyms: DBPR211

CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.

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CB1-IN-1 Chemical Structure
CB1-IN-1, CAS 1429239-98-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
2 mg In stock $ 197.00
5 mg In stock $ 333.00
10 mg In stock $ 477.00
25 mg In stock $ 782.00
50 mg In stock $ 1,090.00
100 mg In stock $ 1,470.00
500 mg In stock $ 2,950.00
1 mL * 10 mM (in DMSO) In stock $ 397.00
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Purity: 99.55%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
Targets&IC50 CB2 receptor:21 nM, CB1 receptor:0.3 nM
Synonyms DBPR211
Molecular Weight 751.67
Formula C33H31Cl2F3N6O3S2
CAS No. 1429239-98-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (14.63 mM)

TargetMolReferences and Literature

1. Chang C P , Wu C H , Song J S , et al. Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.[J]. Journal of Medicinal Chemistry, 2013, 56(24):9920. 2. Chang C P , Huang H L , Huang J K , et al. Fluorine-18 Isotope Labeling for Positron Emission Tomography Imaging. Direct Evidence for DBPR211 as a Peripherally Restricted CB1 Inverse Agonist[J]. Bioorganic & Medicinal Chemistry, 2018.

TargetMolCitations

1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library GPCR Compound Library Inhibitor Library Mitochondria-Targeted Compound Library Neuronal Signaling Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library Bioactive Compounds Library Max ReFRAME Related Library NO PAINS Compound Library

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Keywords

CB1-IN-1 1429239-98-4 GPCR/G Protein Cannabinoid Receptor DBPR 211 Inhibitor DBPR211 inhibit BPRCB 1184 CB1IN1 BPRCB-1184 BPRCB1184 CB-1-IN-1 CB1 IN 1 DBPR-211 inhibitor

 

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