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CB1-IN-1

Catalog No. T5996 CAS 1429239-98-4

Synonyms: DBPR211, 1-(2,4-二氯苯基)-N-1-哌啶基-4-[[(1-吡咯烷基磺酰基)氨基]甲基]-5-[5-[2-[4-(三氟甲基)苯基]乙炔基]-2-噻吩基]-1H-吡唑-3-甲酰胺

CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.

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CB1-IN-1, CAS 1429239-98-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
Targets&IC50	CB2R:21 nM, CB1R:0.3 nM

Synonyms	DBPR211, 1-(2,4-二氯苯基)-N-1-哌啶基-4-[[(1-吡咯烷基磺酰基)氨基]甲基]-5-[5-[2-[4-(三氟甲基)苯基]乙炔基]-2-噻吩基]-1H-吡唑-3-甲酰胺
Molecular Weight	751.67
Formula	C33H31Cl2F3N6O3S2
CAS No.	1429239-98-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chang C P , Wu C H , Song J S , et al. Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.[J]. Journal of Medicinal Chemistry, 2013, 56(24):9920. 2. Chang C P , Huang H L , Huang J K , et al. Fluorine-18 Isotope Labeling for Positron Emission Tomography Imaging. Direct Evidence for DBPR211 as a Peripherally Restricted CB1 Inverse Agonist[J]. Bioorganic & Medicinal Chemistry, 2018.

Citations

1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Neuronal Signaling Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library

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Related compounds with same targets

CB2R/FAAH modulator-1 CB2R/FAAH modulator-3 Virodhamine ML192 AZD1940 SCH-336 Tedalinab SR144528

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CB1-IN-1 1429239-98-4 G蛋白偶联受体 Cannabinoid Receptor Inhibitor inhibit BPRCB 1184 CB1IN1 BPRCB-1184 BPRCB1184 DBPR211 CB-1-IN-1 CB1 IN 1 inhibitor

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