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BD1063 dhydrochloride

Name: BD1063 dhydrochloride
Brand: TargetMol
SKU: T7488
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7488Cas No. 206996-13-6

Alias BD1063 2HCL

BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).

BD1063 dhydrochloride

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Purity: 99.52%

Catalog No. T7488Alias BD1063 2HCLCas No. 206996-13-6

BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).

Pack Size	Price	Availability
2 mg	$41	In Stock
5 mg	$66	In Stock
10 mg	$92	In Stock
25 mg	$197	In Stock
50 mg	$357	In Stock
100 mg	$525	In Stock
200 mg	$739	In Stock
500 mg	$1,130	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).
In vivo	BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls[1]
Animal Research	Rats (controls, N=11;?dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design.?sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design[1].
Synonyms	BD1063 2HCL

Chemical Properties

Molecular Weight	346.12
Formula	C₁₃H₂₀Cl₄N₂
Cas No.	206996-13-6
Smiles	Cl.Cl.CN1CCN(CCc2ccc(Cl)c(Cl)c2)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (144.46 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.8892 mL	14.4459 mL	28.8917 mL	144.4586 mL
5 mM	0.5778 mL	2.8892 mL	5.7783 mL	28.8917 mL
10 mM	0.2889 mL	1.4446 mL	2.8892 mL	14.4459 mL
20 mM	0.1445 mL	0.7223 mL	1.4446 mL	7.2229 mL
50 mM	0.0578 mL	0.2889 mL	0.5778 mL	2.8892 mL
100 mM	0.0289 mL	0.1445 mL	0.2889 mL	1.4446 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc