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BD1063 dhydrochloride

Catalog No. T7488 CAS 206996-13-6

Synonyms: BD1063

BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).

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BD1063 dhydrochloride, CAS 206996-13-6

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Purity: 98%

Biological Description

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Description	BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
In vivo	BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls[1]
Animal Research	Rats (controls, N=11;?dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design.?sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design[1].

Synonyms	BD1063
Molecular Weight	346.12
Formula	C13H20Cl4N2
CAS No.	206996-13-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 50 mg/mL (144.46 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sabino V , Cottone P , Zhao Y , et al. The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking[J]. Neuropsychopharmacology, 2009, 34(6):1482-1493. 2. Nieto F R , Cruz Miguel Cendán, Cristina Sánchez-Fernández, et al. Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice[J]. The journal of pain: official journal of the American Pain Society, 2012, 13(11):1107-1121.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Neurotransmitter Receptor Compound Library Inhibitor Library Neuronal Signaling Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

BMY-14802 Siramesine L-745870 trihydrochloride BMY-14802 hydrochloride BD 1008 dihydrobromide Glycerol phenylbutyrate-D5 Glycerol phenylbutyrate-D15 S1RA

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BD1063 dhydrochloride 206996-13-6 G蛋白偶联受体 Sigma receptor Sigma Receptor Inhibitor inhibit BD1063 BD-1063 dhydrochloride inhibitor

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