Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 143.00 | |
5 mg | In stock | $ 412.00 | |
10 mg | In stock | $ 613.00 | |
25 mg | In stock | $ 977.00 | |
50 mg | In stock | $ 1,320.00 | |
100 mg | In stock | $ 1,780.00 |
Description | Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor. |
Targets&IC50 | NK1:Ki: 0.175 nM (Human), , NK2:ki:560 nM (Human) |
In vitro | Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1]. |
In vivo | Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1]. |
Molecular Weight | 1473.72 |
Formula | C63H104N22O17S |
CAS No. | TP1772L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Hemokinin 1 (mouse) acetate(208041-90-1 free base) TP1772L GPCR/G Protein Neuroscience Neurokinin receptor Hemokinin 1 (mouse) acetate(208041901 free base) Hemokinin 1 (mouse) acetate(208041 90 1 free base) Hemokinin 1 acetate(208041-90-1 free base) inhibitor inhibit