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Catalog No. T11909   CAS 1346133-11-6
Synonyms: FP3FBZ

LY2444296 is an orally active and selective antagonist of kappa Opioid Receptor(Ki = 1 nM).

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LY2444296, CAS 1346133-11-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 66.00
10 mg In stock $ 124.00
25 mg In stock $ 217.00
50 mg In stock $ 315.00
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Purity: 98.03%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LY2444296 is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
Targets&IC50 KOPR(ki):ki: ~1 nM
In vivo LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2].
Synonyms FP3FBZ
Molecular Weight 408.44
Formula C24H22F2N2O2
CAS No. 1346133-11-6


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 25.2mg/mL (61.7mM), Need ultrasonic

Methanol: 5 mg/mL (12.24 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20. 2. Valenza M, et al. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Neurotransmitter Receptor Compound Library

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ADL-5747 Propiram fumarate HCl BPR1M97 6'-GNTI dihydrochloride JNJ-20788560 ORL1 antagonist 1 AT-121 Deltorphin acetate

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LY2444296 1346133-11-6 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor FP3FBZ inhibitor inhibit