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LY2444296

Catalog No. T11909 CAS 1346133-11-6

Synonyms: FP3FBZ

LY2444296 is an orally active and selective antagonist of kappa Opioid Receptor(Ki = 1 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LY2444296, CAS 1346133-11-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 66.00
10 mg	In stock	$ 124.00
25 mg	In stock	$ 217.00
50 mg	In stock	$ 315.00

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Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2444296 is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
Targets&IC50	KOPR(ki):ki： ~1 nM
In vivo	LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2].

Synonyms	FP3FBZ
Molecular Weight	408.44
Formula	C24H22F2N2O2
CAS No.	1346133-11-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 25.2mg/mL (61.7mM), Need ultrasonic

Methanol: 5 mg/mL (12.24 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20. 2. Valenza M, et al. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231.

Related compound libraries

This product is contained In the following compound libraries：

Neuronal Signaling Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Neurotransmitter Receptor Compound Library

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Related compounds with same targets

ADL-5747 Propiram fumarate HCl BPR1M97 6'-GNTI dihydrochloride JNJ-20788560 ORL1 antagonist 1 AT-121 Deltorphin acetate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY2444296 1346133-11-6 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor FP3FBZ inhibitor inhibit

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