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Cat No. | Product Name | Synonyms | Targets |
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T82494 | EGFP mRNA-LNP | ||
eGFP mRNA-LNP is a lipid nanoparticle encapsulating eGFP mRNA, designed for assessments of RNA delivery, translation efficiency, and cell viability. The eGFP mRNA, once internalized by cells, expresses Enhanced Green Flu... | |||
T75103 | CD19 CAR mRNA | ||
CD19 CAR mRNA is designed to express the CD19 chimeric antigen receptor (CAR) protein, pivotal in chimeric antigen receptor T cell (CAR-CD19) immunotherapy. This receptor targets CD19, a membrane antigen crucial for B ce... | |||
T75114 | CD19 car mRNA-LNP | ||
CD19 car mRNA-LNP, a lipid nanoparticle (LNP) encapsulating CD19 car mRNA, is instrumental in assessing RNA delivery, translation efficacy, and cell viability among other applications. This compound is pivotal for chimer... | |||
T75116 | COVID-19 Spike Protein mRNA-LNP | ||
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) formulated with the novel coronavirus pneumonia spike protein, positioned on the membrane surface, designed for applications such as RNA delivery, translation... | |||
T82495 | EGFP mRNA(N1-Me-Pseudo UTP) | ||
eGFP mRNA encodes the green fluorescent protein, originally derived from the jellyfish Aequorea victoria, and serves as a widely utilized direct detection reporter in mammalian cell culture. This protein produces a disti... | |||
T82397 | Firefly Luciferase mRNA(N1-Me-Pseudo UTP) | ||
Firefly Luciferase mRNA, derived from Photinus pyralis (Firefly), codes for a bioluminescent enzyme widely utilized as a reporter in gene regulation and function analyses. This enzyme facilitates assays pertaining to gen... | |||
T75102 | COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP) | ||
The COVID-19 Spike Protein mRNA, responsible for expressing the COVID-19 spike protein, is crucial for evaluating RNA delivery, translation efficiency, and cell viability. Positioned on the membrane surface, this spike p... | |||
T1481 | Fudosteine | Others | |
Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. | |||
T35648 | 4-Thiouridine | Others | |
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directl... | |||
T9410 | SM-102 | Others | |
SM-102 is an ionizable amino lipid utilized in the synthesis of lipid nanoparticles (LNPs)[1]. It exhibits promise in the creation of LNPs dedicated to the transportation of mRNA-based vaccines[2]. | |||
T7138 | FB23-2 | Apoptosis , Others | |
FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM). | |||
T22089 | HPI 1 | Hedgehog/Smoothened | |
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... | |||
T16698 | Pyronin Y | C.I. 45005,Pyronine G | Others |
Pyronin Y (Pyronine G) is an intercalating cationic dye that shows specificity towards RNA. | |||
T10760 | Ceramides Mixture | Telomerase | |
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activ... | |||
T8972 | FIT-039 | Others , DNA/RNA Synthesis , CDK , HSV | |
FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr... | |||
T19459 | N1-Methylpseudouridine | 1-Methylpseudouridine | Others |
N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density in mRNA. | |||
T0717L | Enoxacin | NSC 629661,AT 2266,Pd107779,CI 919 | DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic |
Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | |||
T9854 | HIV-1 inhibitor-6 | 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- | HIV Protease |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication. | |||
T0717 | Enoxacin hydrate | CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate | DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic |
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. | |||
T9033 | BTYNB | MDK6620,BTYNB IMP1 Inhibitor | Others , c-Myc , NF-κB |
BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa ... | |||
T16886 | Sinefungin | Adenosyl-Ornithine,A-9145,Antibiotic 32232RP | Others , Histone Methyltransferase , Antibiotic , Antifungal |
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r... | |||
T9980 | AVJ16 | IGF-1R | |
AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation. | |||
T17034 | Temarotene | Ro 15-0778 | Others |
Temarotene (Ro 15-0778) is an orally active and potent small molecule compound that modulates human immune function in vitro.Temarotene may be used in the study of lichen planus. | |||
T38604 | C12-200 | C12-200 | Others |
C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids and can be used in the delivery of mRNA. | |||
T9640 | Diethylnorspermine HCl | Diethylnorspermine tetrahydrochloride,N1,N11-Diethylnorspermine tetrahydrochloride,DENSPM tetrahydrochloride | Others |
Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectively stabilizes SSAT enzyme activity. | |||
T77945 | TriGalNAc CBz | LYTACs | |
TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide. | |||
T16757 | Risdiplam | RO7034067,RG7916 | DNA/RNA Synthesis |
Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1]. | |||
T14847 | B I09 | Others , IRE1 | |
B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cel... | |||
TP2109L | AT 14 acetate | Nrf2 | |
TAT 14 acetate, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT 14 acetate increases Nrf2 protein levels due to targeting the Nrf2 binding site on Keap1, but has no effect on Nrf2 mRNA expre... | |||
T4658 | MHP | Methyl caprooyl tyrosinate | S1P Receptor |
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. | |||
T9565 | OSBPL7-IN-1 | Others | |
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. | |||
T21325 | TAK-441 | TAK441 | Hedgehog/Smoothened |
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth. | |||
T16015 | Maxacalcitol | 22-Oxacalcitriol | Others |
Maxacalcitol (22-Oxacalcitriol) is a ligand of VDR-like receptors and a non-serum calcium vitamin D3 analogue. Maxacalcitol inhibits parathyroid hormone (PTH) mRNA expression in vitro and in vivo. | |||
T17181 | TVB-3664 | Fatty Acid Synthase | |
TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50: 18 nM and 12 nM for human and mouse cell palmitate synthe... | |||
T9277 | ALC-0315 | ||
ALC-0315 is an ionizable amino lipid that has been used in combination with other lipids to form lipid nanoparticles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine | |||
T73475 | SMN-C2 | DNA/RNA Synthesis | |
SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.SMN-C2 has the potential to be used in the... | |||
T8874 | FB23 | Others | |
FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.) | |||
T3265 | Azathramycin | Desmethyl Azithromycin,6-Demethylazithromycin,Azaerythromycin A,Azaerythromycin | Antibacterial , Antibiotic |
Azathramycin (Desmethyl Azithromycin) is an antibiotic derived from erythromycin, binding to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. | |||
T12781 | RV01 | Others | |
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc... | |||
T67767 | HIF-1 inhibitor-4 | HIF-1 inhibitor-4 | HIF |
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level. | |||
T3147 | Pyrrolidinedithiocarbamate ammonium | PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate | NF-κB |
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. | |||
T13492 | 3,5-Diiodothyropropionic acid | C082182,Ditpa cpd | Thyroid hormone receptor(THR) |
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1). | |||
T39965 | NF-κΒ activator 1 | NF-κB | |
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide ... | |||
T60619 | CDK9-IN-15 | CDK | |
CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-terminal region of RNA Poly-II by degradation and inhibition of CD... | |||
T12574 | PTC299 | Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate | VEGFR , Dehydrogenase |
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at t... | |||
T27392 | FT001 | Epigenetic Reader Domain | |
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects ag... | |||
T3628 | Madrasin | DDD00107587 | DNA/RNA Synthesis |
Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. | |||
T14083 | Abaperidone | Dopamine Receptor , 5-HT Receptor | |
Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th... | |||
T23897 | CLK1/2-IN-3 | CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3 | CDK |
CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, wh... | |||
T16551 | Pladienolide B | Apoptosis | |
Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pr... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16674 | Pseudouridine | Endogenous Metabolite | |
Pseudouridine is the most abundant modified nucleoside in non-coding RNAs. It enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure. | |||
T5S0246 | Pseudoprotodioscin | Others , Fatty Acid Synthase | |
1. Pseudoprotodioscin has moderate cytotoxicity. | |||
TQ0218 | Deoxyandrographolide | 14-deoxyandrographolide | IL Receptor , TNF |
Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6. | |||
TN1465 | Cannabigerol | NOS , 5-HT Receptor , ROS | |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... | |||
T17143 | Toyocamycin | Vengicide | Apoptosis , Others , IRE1 , Antibiotic , Antifungal |
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis. | |||
T2A2481 | Taurochenodeoxycholic Acid | Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine | Apoptosis , TNF , Caspase , Endogenous Metabolite |
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. | |||
TN2215 | Taurochenodeoxycholic acid sodium | Sodium taurochenodeoxycholate | Apoptosis , Endogenous Metabolite |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and... | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
TN2331 | Eleutheroside B1 | Influenza Virus | |
Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits l... | |||
T4S0181 | Hinokiflavone | MMP , BCL , E1/E2/E3 Enzyme | |
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO... | |||
T3809 | Liriope muscari baily saponins C | Others | |
Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6. | |||
T5S1981 | Alpha-Cyperone | (+)-α-Cyperone,α-Cyperone | Others , Endogenous Metabolite |
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced... | |||
T21430 | Oxytetracycline Hydrochloride | Biosolvomycin,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin | Antiviral , Endogenous Metabolite , Antibacterial , HSV |
Oxytetracycline Hydrochloride (Dalimycin) is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity. It interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, resultin... | |||
T6S2023 | Harpagoside | Others , COX , NO Synthase | |
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression... | |||
T4S0795 | Berberrubine chloride | 9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline | IL Receptor |
1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expressio... | |||
T5727 | CAFESTOL | ERK , NF-κB , COX , PGE Synthase | |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... | |||
T2S0410 | Euphorbia factor L1 | Euphorbiasteroid | Apoptosis , P-gp |
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant... | |||
T2845 | Imperatorin | Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen | TRP/TRPV Channel , AChR , AChE , NOD |
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. | |||
T6430 | Calcifediol | U 32070E,25-hydroxy Vitamin D3,RO 8-8892 | Endogenous Metabolite |
Calcifediol (U 32070E)(Ki of 3.9 μM), a major circulating metabolite of vitamin D3, works as a competitive inhibitor. It (ED50=2 nM)also inhibits PTH secretion and mRNA. | |||
T1104 | Paromomycin Sulfate | Aminosidine sulfate,Paromomycin sulfate salt | Antibacterial , Antibiotic , Parasite |
Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed... | |||
T3889 | Platycodin D | Prostaglandin Receptor , AMPK | |
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1... | |||
T3918 | Ginsenoside Rb3 | Gypenoside IV | NF-κB , COX , NO Synthase |
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA. | |||
TN2080 | Pinoresinol | (+)-Pinoresinol | Apoptosis , NF-κB , CDK , p53 |
Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative st... | |||
T3S1701 | Dihydrocurcumin | PPAR , Fatty Acid Synthase | |
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, incr... | |||
T3729 | Ethyl gallate | Nipagallin A,Phyllemblin,gallic acid ethyl ester | MMP , NF-κB , Akt , Antibacterial |
Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib... | |||
TMS1461 | Qingyangshengenin B | Otophylloside B | Beta Amyloid |
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR... | |||
T5S2228 | 6‴-Feruloylspinosin | 6'''-Feruloylspinosin | NF-κB |
6‴-Feruloylspinosin (6'''-Feruloylspinosin) may possess anti-inflammatory activity. | |||
TN2091 | Polygalacin D | Apoptosis , IAP | |
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxi... | |||
T4S21320 | ISOGINKGETIN | 4',4'''-Dimethylamentoflavone | MMP , Others |
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... | |||
T3S0175 | Gardenia yellow | alpha-Crocin,Crocin I,Crocine | Sirtuin |
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects. | |||
TWO2727 | Propane-1,2,3-triyl tripalmitate | Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate | Others , Endogenous Metabolite |
Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. Tripalmitin increases body weight and plasma LDL levels and reduces hepatic LDL receptor mRNA levels in hamsters fed a ... | |||
T0912 | Tetracycline hydrochloride | NCI-c55561,Tetracycline HCl | ribosome , Antibacterial , Antibiotic |
Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium ... | |||
T6S1579 | Monotropein | Monotropeine | Others |
1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf... | |||
T2823 | Crocin | Gardenia Yellow,Alpha-Crocin | Others |
Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne... | |||
T5075 | Phytic acid potassium | Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt | Others , Endogenous Metabolite |
Phytic acid potassium (Inositol polyphosphate dipotassium salt) exists in all eukaryotic cells. In plants, it is known to function as a [PO4]3 storage depot and precursor for other inositol phosphates and pyrophosphates.... | |||
T5S0285 | Cistanoside A | Others | |
1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat... | |||
T13818 | Phytohemagglutinin | PHA-M | Apoptosis |
Phytohemagglutinin (PHA-M) is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tumor activity | |||
T0683 | Mevastatin | Compactin,ML236B | Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid |
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. | |||
TN1291 | 7,3',4'-Tri-O-methylluteolin | 5-Hydroxy-3',4',7-trimethoxyflavone | TNF , COX , Interleukin |
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T4S1469 | Cucurbitacin IIb | Apoptosis , Others | |
1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-i... | |||
T2762 | Kasugamycin hydrochloride | Kasumin | Antibacterial , Antibiotic , Antifungal |
Kasugamycin hydrochloride (Kasumin) is an aminoglycoside antibiotic that was originally isolated in 1965, from Streptomyces kasugaensis, a Streptomyces strain found near the Kasuga shrine in Nara, Japan. Kasugamycin hydr... | |||
T6S1487 | Ginsenoside Rg5 | NF-κB , COX , IGF-1R | |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ... | |||
TN3614 | Cearoin | ERK , BCL , PARP , IκB/IKK , TNF , NF-κB , ROS , Caspase | |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of... | |||
T30048 | Anemonin (6CI) | Pulsatilla camphor,Anemonin,Anemone camphor | |
Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis pro... | |||
TN4446 | Longiferone B | NOS , COX | |
Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression. | |||
T38890 | Thailanstatin C | ||
Thailanstatin C, an antiproliferative agent derived from Burkholderia thailandensis MSMB43, functions as a potent inhibitor of pre-mRNA splicing (IC50 = 6.84 μM). | |||
T27191 | D-Mannuronic Acid | ||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. | |||
T77289 | 5-O-Methylembelin | ||
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9 , low-density lipoprotein receptor (IDOL) , and sterol regulatory element binding protein 2 (SREBP2) mRNA expression [1] . | |||
T40483 | 8-Aminoadenosine | 8-NH2-Ado | |
8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy... | |||
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Cat No. | Product Name | Species | Expression System |
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TMPK-01308 | TAG-72 Protein, Canine, Recombinant (His) | Canine | E. coli |
The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA... | |||
TMPH-01631 | DCP2 Protein, Human, Recombinant (His) | Human | E. coli |
DCP2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.4 kDa and the accession number is Q8IU60. | |||
TMPY-03390 | LSM1 Protein, Human, Recombinant (His) | Human | E. coli |
LSM1 is an Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions ... | |||
TMPJ-00345 | IGF2BP-2 Protein, Human, Recombinant (His) | Human | E. coli |
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to... | |||
TMPH-03432 | ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His) | Saccharomyces cerevisiae | E. coli |
Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nucle... | |||
TMPH-03431 | ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His) | Saccharomyces cerevisiae | E. coli |
Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nucle... | |||
TMPY-03599 | RPRD1B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phospho... | |||
TMPY-01762 | IGF2BP-2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the IGF-II mRNA-binding protein (IMP) family. IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to b... | |||
TMPH-01457 | Human herpesvirus 6B (HHV-6 variant B) (strain Z29) mRNA export factor ICP27 homolog (His & Myc) | HHV-6B | E. coli |
Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs. Human herpesvirus 6B (HHV-6 variant B) (strain Z29... | |||
TMPJ-00507 | EIF4E Protein, Human, Recombinant | Human | E. coli |
Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and int... | |||
TMPH-03712 | Clp1 Protein, Xenopus laevis, Recombinant (His) | Xenopus laevis | E. coli |
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated mo... | |||
TMPJ-00705 | BCAS2 Protein, Human, Recombinant (His, T7) | Human | E. coli |
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell li... | |||
TMPJ-00712 | MPZL1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface ... | |||
TMPJ-00651 | CD155/PVR Protein, Human, Recombinant (aa 21-343, His) | Human | HEK293 Cells |
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entr... | |||
TMPJ-00154 | IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells) | Mouse | HEK293 Cells |
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, o... | |||
TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4... | |||
TMPH-01282 | ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th... | |||
TMPH-02883 | RBFOX3 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). | |||
TMPH-01313 | EIF4G1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c... | |||
TMPH-02228 | TRA2B Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor ne... | |||
TMPH-01312 | EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) | Human | E. coli |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c... | |||
TMPH-00744 | CsrA Protein, E. coli, Recombinant | E. coli | E. coli |
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress... | |||
TMPH-01281 | ELAVL3 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in ... | |||
TMPH-00102 | RBP47A Protein, Arabidopsis thaliana, Recombinant (His & Myc) | Arabidopsis thaliana | E. coli |
Heterogeneous nuclear ribonucleoprotein (hnRNP)-protein binding the poly(A) tail of mRNA and probably involved in some steps of pre-mRNA maturation. RBP47A Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expres... | |||
TMPH-02133 | DDX39B Protein, Human, Recombinant (GST) | Human | E. coli |
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mR... | |||
TMPY-03748 | BCL2L12 Protein, Human, Recombinant (GST) | Human | E. coli |
BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the predicti... | |||
TMPY-03344 | LSM3 Protein, Human, Recombinant (His) | Human | E. coli |
LSM3 (LSM3 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. LSM3 is a member of the snRNP Sm proteins family. It plays role in pre-mRNA splicing as a component of the U4/U6-U5 tri-... | |||
TMPH-02229 | TRA2B Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor ne... | |||
TMPH-02317 | YTHDF1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stabi... | |||
TMPH-03444 | GCY1 Protein, S. cerevisiae, Recombinant (His) | Saccharomyces cerevisiae | P. pastoris (Yeast) |
Glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. Has mRNA binding activity. GCY1 Protein, S. cerevisiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecu... | |||
TMPH-01704 | RAE1 Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. RAE1 Protein, Human, Recombinant (... | |||
TMPY-03286 | HnRNP-R Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
HNRNP R, also known as HNRNPR, is an RNA binding protein. HNRNP R gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). HnRNPs complex with heterogeneous nuclear RNA (... | |||
TMPH-01584 | KRT7 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). | |||
TMPH-01462 | HNRNPH1 Protein, Human, Recombinant (GST) | Human | E. coli |
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in ... | |||
TMPH-00673 | NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His) | E. coli | E. coli |
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosph... | |||
TMPY-01557 | MAGOH Protein, Human, Recombinant (His) | Human | E. coli |
MAGOH (Mago Homolog, Exon Junction Complex Subunit) is a Protein Coding gene. MAGOH is the human homolog of Drosophila mago nashi, a protein that is required for normal germplasm development in the Drosophila embryo. In ... | |||
TMPH-02312 | Wilms tumor protein/WT1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO.... | |||
TMPH-01224 | Dihydrofolate reductase Protein, Human, Recombinant (His) | Human | E. coli |
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds... | |||
TMPJ-00676 | PPIH Protein, Human, Recombinant (His) | Human | E. coli |
Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline Imidic peptide bonds in olig... | |||
TMPH-00562 | 30S ribosomal protein S7 Protein, E. coli, Recombinant (His) | E. coli | E. coli |
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has be... | |||
TMPJ-01297 | WIBG Protein, Human, Recombinant (His) | Human | E. coli |
Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC). EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs, is a positional landmarker for ... | |||
TMPY-00471 | INSL4 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
INSL4 (Insulin-Like 4) is a Protein Coding gene. An important paralog of this gene is RLN1. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary st... | |||
TMPK-00224 | BTN3A2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
BTN3A2/BT3.2 butyrophilin mRNA expression by tumoral cells was previously identified as a prognostic factor in a small cohort of high grade serous epithelial ovarian cancer (HG-EOC).In conclusion, BT3.2 protein is a pote... | |||
TMPY-04732 | Fibrinogen Gamma Chain Protein, Human, Recombinant | Human | P. pastoris (Yeast) |
Loss of function mutations in FGG have been associated with fibrinogen deficiency. FGG mRNA was expressed abnormally in HCC and elevated plasma fibrinogen may serve as a useful predictor of clinical progression of HCC pa... | |||
TMPJ-01007 | HRSP12 Protein, Human, Recombinant (His) | Human | E. coli |
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA... | |||
TMPH-01461 | HNRNPA3 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. HNRNPA3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression sys... | |||
TMPY-02797 | TXNL4A Protein, Human, Recombinant (His) | Human | E. coli |
DIM1, also known as TXNL4A, is a member of the Dim protein family. The Dim protein family is composed of two classes, DIM1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their ro... | |||
TMPH-03288 | EIF3I Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates ... | |||
TMPH-03289 | EIF3I Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates ... | |||
TMPH-03565 | MazF Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the f... | |||
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Cat No. | Product Name | ||
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L9420 | Exosome Compound Library | 76 compounds | |
76 exosome-related compounds that can be used for high-throughput and high-content screening. | |||
L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; |