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Paromomycin Sulfate

Catalog No. T1104   CAS 1263-89-4
Synonyms: Aminosidine sulfate, Paromomycin sulfate salt

Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.

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Paromomycin Sulfate Chemical Structure
Paromomycin Sulfate, CAS 1263-89-4
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Purity: 99.82%
Purity: 99.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.
Kinase Assay Concentration–response and kinetic studies: The microsomal protein (30 μg), [1β-3H]androstenedione (6.6 × 105 dpm) and NADPH (270 μM) are used for the concentration–response experiment with an incubation time of 20 minutes. The Aminoglutethimide is initially tested at 10 μM and 100 μM concentrations, followed by a full concentration–response study with at least 8 concentrations ranging from 0.01 μM to 160 μM. For the initial velocity study the concentration of [1β-3H]androstenedione is varied from 7.5 to 100 nM and the incubation time is set to 5 minutes. The tritiated water formed during the conversion of the tritiated substrate, [1β-3H]androstenedione, to estrone is quantified by liquid scintillation counting. Each assay is performed three times in duplicate and the results are treated by nonlinear regression analysis allowing the determination of the half-maximal inhibitory concentration (IC50).
Synonyms Aminosidine sulfate, Paromomycin sulfate salt
Molecular Weight 713.71
Formula C23H47N5O18S
CAS No. 1263-89-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

TargetMolReferences and Literature

1. Davidson RN, et al. ParomomycinTrans R Soc Trop Med Hyg, 2009, 103(7), 653-660. 2. Simon L. Croft, et al. Clin Microbiol Rev, 2006, 19(1), 111-126 3. Li Zhu, Ruonan Liu, Tangrong Liu, Xuan Zou, Zhe Xu, Huashi Guan. A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis. 2019 Feb 5;164:520-527.

TargetMolCitations

1. Xu G, Li T, Chen J, et al. Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1mRNA splicing. Autophagy. 2018, 14(10): 1818-1830

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Antiparasitic Natural Product Library Anti-Parasitic Compound Library Anti-Infection Compound Library Clinical Compound Library Bioactive Compounds Library Max Drug-induced Liver Injury (DILI) Compound Library Anti-Bacterial Compound Library Anti-COVID-19 Compound Library Saccharide and Glycoside Natural Product Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Paromomycin Sulfate 1263-89-4 Microbiology/Virology Antibiotic Antibacterial Parasite Inhibitor parasitic Aminosidine giardiasis tapeworm infection Aminosidine sulfate amebiasis Aminosidine Sulfate inhibit Bacterial leishmaniasis Paromomycin sulfate salt Paromomycin inhibitor

 

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