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TVB-3664

Catalog No. T17181 CAS 2097262-58-1

TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50: 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively).

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TVB-3664, CAS 2097262-58-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 141.00
5 mg	In stock	$ 344.00
10 mg	In stock	$ 571.00
25 mg	In stock	$ 861.00
50 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 359.00

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Purity: 99.28%

Purity: 99.17%

Purity: 99.06%

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Description	TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50: 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively).
Targets&IC50	FASN:18 nM
In vitro	TVB-3664 reduces viability in multiple tumor cell lines from solid and hematopoietic tumor types. TVB-3664 (0-1 μM, 7 days) displays anti-tumor activity in CaCo2, HT29, and LIM2405 cell lines [1].
In vivo	In Pt 2614, Pt 2449PT, and Pt 2402 PDX models, TVB-3664 (3 mg/kg or 6 mg/kg, oral gavage, daily, 4 weeks) treatment leads to a significant reduction in tumor volume and tumor weight, with an average reduction in tumor weight of 30%, 37.5%, and 51.5%, respectively [1].

Molecular Weight	468.47
Formula	C25H23F3N4O2
CAS No.	2097262-58-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (17.08mM)

References and Literature

1. Zaytseva YY, et al. Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget. 2018 May 15;9(37):24787-24800. 2. Heuer TS, et al. FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression. EBioMedicine. 2017 Feb;16:51-62.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Inhibitor Library Metabolism Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library Anti-Obesity Compound Library Anti-Cancer Metabolism Compound Library Lipid Metabolism Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TVB-3664 2097262-58-1 Metabolism Fatty Acid Synthase Inhibitor TVB3664 TVB 3664 Fatty Acid Synthase (FASN) inhibit inhibitor

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