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Euphorbia factor L1

Catalog No. T2S0410Cas No. 76376-43-7
Alias Euphorbiasteroid

Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.

Euphorbia factor L1

Euphorbia factor L1

Purity: 99.74%
Catalog No. T2S0410Alias EuphorbiasteroidCas No. 76376-43-7
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.
Pack SizePriceAvailabilityQuantity
20 mg$100In Stock
1 mL x 10 mM (in DMSO)$80In Stock
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Purity:99.74%
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Product Introduction

Bioactivity
Description
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.
In vitro
Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2].
Cell Research
3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50?μM for 2?days in adipogenesis induction medium, 2?days in adipogenesis medium and 2?days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution.
AliasEuphorbiasteroid
Chemical Properties
Molecular Weight552.66
FormulaC32H40O8
Cas No.76376-43-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Methanol: Soluble
DMSO: 37 mg/mL (66.9 mM)
Ethanol: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8094 mL9.0472 mL18.0943 mL90.4715 mL
5 mM0.3619 mL1.8094 mL3.6189 mL18.0943 mL
10 mM0.1809 mL0.9047 mL1.8094 mL9.0472 mL
20 mM0.0905 mL0.4524 mL0.9047 mL4.5236 mL
50 mM0.0362 mL0.1809 mL0.3619 mL1.8094 mL

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