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Euphorbia factor L1

Catalog No. T2S0410 CAS 76376-43-7

Synonyms: Euphorbiasteroid

1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 and MCF-7/adr cells, does not downregulate their expression either in mRNA or protein level.

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Euphorbia factor L1, CAS 76376-43-7

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 100.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 99.74%

Purity: 98%

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Description	1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 and MCF-7/adr cells, does not downregulate their expression either in mRNA or protein level.
In vitro	Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2].
Cell Research	3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50?μM for 2?days in adipogenesis induction medium, 2?days in adipogenesis medium and 2?days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution.
Source	Natural Products > Euphorbiaceae > Euphorbia

Synonyms	Euphorbiasteroid
Molecular Weight	552.66
Formula	C32H40O8
CAS No.	76376-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Methanol: Soluble

DMSO: 37 mg/mL(66.9 mM)

Ethanol: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Park SJ, et al. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinase.Cell Biochem Funct. 2015, 33(4):220-5. 2. Jung Sook Choi, et al. Euphorbiasteroid reverses P‐glycoprotein‐mediated multi‐drug resistance in human sarcoma cell line MES‐SA/Dx5.Phytotherapy research. 2010, 24(7):1042-1046.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Neuronal Signaling Compound Library Anti-Tumor Natural Product Library Traditional Chinese Medicine Monomer Library Ion Channel Inhibitor Library Macrocyclic Compound Library NO PAINS Compound Library Apoptosis Compound Library Natural Product Library Selected Plant-Sourced Compound Library

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Keywords

Euphorbia factor L1 76376-43-7 Apoptosis Membrane transporter/Ion channel Neuroscience P-gp Euphorbia factor L-1 Euphorbiasteroid inhibitor inhibit

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