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TargetMol | Compound Library

NF-κB Signaling Compound Library

Catalog No. L3800

Nuclear factor-κB (NF-κB), a collective term for a family of transcription factors, includes five subunits: NF-κB1 (p50/p105), NF-κB2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the κB site on their target genes for DNA interaction and transcriptional activation. How NF-κB selectively recognizes a small subset of relevant κB sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase(IKK). IKK, in turn, phosphorylates the IκBα protein, which results in ubiquitination, dissociation of IκBα from NF-κB, and eventual degradation of IκBα by the proteasome. The activated NF-κB is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-κB complex then recruits other proteins such as coactivators and RNA polymerase, which transcribe downstream DNA into mRNA. A large array of genes involved in different processes of the immune and inflammatory responses, such as TNF-α, IL-1β, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-κB. In TNF-α–induced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity. NF-κB Signaling Compound Library from TargetMol, a unique collection of 729 small molecules targeting NF-κB signaling, can be used for research in NF-κB signaling and high throughput screening and high content screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3800

NF-κB Signaling Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
  • Effective tool for research in NF-κB signaling and related drug screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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can be highly customized!
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Library Customization | TargetMol Library Composition

NF-κB
Reactive Oxygen Species
Apoptosis
TNF
Autophagy
Endogenous Metabolite
Antibacterial
COX
IκB/IKK
IL Receptor
RIP kinase
NOD
Antioxidant
ERK
p38 MAPK
NO Synthase
IRAK
JNK
STAT
Interleukin
TLR
PPAR
Akt
Nrf2
HIV Protease
Ferroptosis
Antifungal
Parasite
ROS
NOD-like Receptor (NLR)
NOS
Cytochromes P450
Calcium Channel
MAPK
Antibiotic
Mitochondrial Metabolism
Lipoxygenase
Influenza Virus
MMP
DNA/RNA Synthesis
HIF/HIF Prolyl-Hydroxylase
PI3K
Mitophagy
Caspase
EGFR
Beta Amyloid
Wnt/beta-catenin
Topoisomerase
PDE
CDK
JAK
AMPK
AChR
Tyrosinase
p53
Dehydrogenase
Cholinesterase (ChE)
HDAC
GABA Receptor
Potassium Channel
Proteasome
Virus Protease
PKC
TRP/TRPV Channel
E1/E2/E3 Enzyme
Prostaglandin Receptor
Bcl-2 Family
Ligand for E3 Ligase
Sodium Channel
Estrogen/progestogen Receptor
Immunology/Inflammation related
Molecular Glues
mTOR
TGF-beta/Smad
PGE Synthase
Sirtuin
Chloride channel
NADPH
RAAS
Histamine Receptor
PKA
Serine/threonin kinase
VEGFR
RANKL/RANK
MAO
LDL
Antifection
Opioid Receptor
IGF-1R
P-gp
Antiviral
HSP
Free radical scavengers
Phospholipase
HIF
FGFR
MEK
Syk
Anti-infection
S6 Kinase
Microtubule Associated
Mdm2
ATPase
Transferase
HCV Protease
Integrin
c-Met/HGFR
LTR
IFNAR
BACE
Glutathione Peroxidase
Phosphatase
GSK-3
Estrogen Receptor/ERR
Leukotriene Receptor
Adrenergic Receptor
IAP
Glucocorticoid Receptor
Glucosidase
HSV
CCR
GluR
DNA
STING
SARS-CoV
AIM2
transporter
Casein Kinase
Retinoid Receptor
PDK
5-HT Receptor
Cannabinoid Receptor
HER
FOXO3
Advanced Glycation End Products
Carbonic Anhydrase
RAR/RXR
MALT
Dopamine Receptor
ROR
Src
MyD88
Adenosine Receptor
Reductase
DYRK
Histone Demethylase
Necroptosis
gp120/CD4
OCT
c-Myc
HBV
Tyrosine Kinases
Pim
Rho
Serine Protease
Cysteine Protease
Liver X Receptor
Amylase
Aryl Hydrocarbon Receptor
iGluR
UGT
Bcr-Abl
PAFR
Haspin Kinase
Gamma-secretase
Drug Metabolite
ABC Transporter
Fatty Acid Synthase
Hedgehog/Smoothened
PAK
PDGFR
PTEN
Somatostatin
Chk
PAD
Aurora Kinase
cAMP
Epigenetic Reader Domain
CaMK
DUB
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
SGLT
OXPHOS
Glutathione reductase
Acyltransferase
LRRK2
Aminopeptidase
Histone Acetyltransferase
cGAS
Pyroptosis
ALK
MELK
RSV
ATM/ATR
GST
Reverse Transcriptase
Adenosine Deaminase
Platelet aggregation
FLT
c-Kit
NADPH-oxidase
FAK
AhR
CFTR
MLK
PKM
Monoamine Oxidase
S1P Receptor
BTK

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