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TargetMol | Compound Library

NF-κB Signaling Compound Library

Catalog No. L3800

Nuclear factor-κB (NF-κB), a collective term for a family of transcription factors, includes five subunits: NF-κB1 (p50/p105), NF-κB2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the κB site on their target genes for DNA interaction and transcriptional activation. How NF-κB selectively recognizes a small subset of relevant κB sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase(IKK). IKK, in turn, phosphorylates the IκBα protein, which results in ubiquitination, dissociation of IκBα from NF-κB, and eventual degradation of IκBα by the proteasome. The activated NF-κB is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-κB complex then recruits other proteins such as coactivators and RNA polymerase, which transcribe downstream DNA into mRNA. A large array of genes involved in different processes of the immune and inflammatory responses, such as TNF-α, IL-1β, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-κB. In TNF-α–induced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity. NF-κB Signaling Compound Library from TargetMol, a unique collection of 729 small molecules targeting NF-κB signaling, can be used for research in NF-κB signaling and high throughput screening and high content screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3800

NF-κB Signaling Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
  • Effective tool for research in NF-κB signaling and related drug screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

NF-κB
Reactive Oxygen Species
Apoptosis
HDAC
Autophagy
TNF
Endogenous Metabolite
ROS
Antibacterial
Nrf2
COX
IκB/IKK
IL Receptor
RIP kinase
p38 MAPK
ERK
NOD
Ferroptosis
Antioxidant
NO Synthase
HIV Protease
IRAK
JNK
Antifungal
Influenza Virus
STAT
Akt
NOD-like Receptor (NLR)
Antibiotic
ROS Kinase
NOS
Mitophagy
P450
Caspase
Calcium Channel
Mitochondrial Metabolism
PPAR
Parasite
Interleukin
Virus Protease
PDE
MMP
Lipoxygenase
EGFR
PI3K
DNA/RNA Synthesis
TLR
ALK
HIF/HIF Prolyl-Hydroxylase
p53
Estrogen/progestogen Receptor
Topoisomerase
CDK
JAK
MAPK
Beta Amyloid
GABA Receptor
Sodium Channel
Tyrosinase
Dehydrogenase
Xanthine Oxidase
AChE
AMPK
Potassium Channel
AChR
MALT
c-Met/HGFR
Proteasome
Wnt/beta-catenin
E1/E2/E3 Enzyme
BCL
Src
NADPH
Adenosine Receptor
VEGFR
TRP/TRPV Channel
MAO
PKC
Gamma-secretase
Antifection
Opioid Receptor
PGE Synthase
HSP
SARS-CoV
Free radical scavengers
Sirtuin
transporter
IGF-1R
Prostaglandin Receptor
Trk receptor
5-HT Receptor
MEK
FGFR
FLT
Ligand for E3 Ligase
HIF
Anti-infection
S6 Kinase
HER
Chloride channel
RAAS
Histamine Receptor
Glutathione Peroxidase
ATPase
Transferase
LTR
IFNAR
PKA
Estrogen Receptor/ERR
RANKL/RANK
Bcr-Abl
Tyrosine Kinases
Leukotriene Receptor
Immunology/Inflammation related
Drug Metabolite
HSV
GluR
CaMK
TGF-beta/Smad
P-gp
STING
Molecular Glues
mTOR
Antiviral
GST
PDK
Casein Kinase
Reverse Transcriptase
Retinoid Receptor
Cannabinoid Receptor
Syk
Microtubule Associated
FAK
Carbonic Anhydrase
ROR
HCV Protease
Reductase
BACE
RAR/RXR 
GSK-3
c-Myc
Mdm2
NPC1L1
Integrin
Necroptosis
OCT
PARP
Serine Protease
Serine/threonin kinase
Adrenergic Receptor
Amylase
iGluR
IAP
Glucocorticoid Receptor
LDL
HBV
Cysteine Protease
Liver X Receptor
Aryl Hydrocarbon Receptor
Haspin Kinase
Glucosidase
BTK
Somatostatin
Chk
Aurora Kinase
cAMP
Epigenetic Reader Domain
DUB
OXPHOS
Glutathione reductase
LRRK2
cGAS
PAK
PDGFR
Hedgehog/Smoothened
CCR
PTEN
PAD
Indoleamine 2,3-Dioxygenase (IDO)
SGLT
Aminopeptidase
Histone Acetyltransferase
ATM/ATR
CFTR
MLK
PKM
RSV
Aromatase
Phospholipase
PLK
Adenosine deaminase
Complement System
Discoidin Domain Receptor (DDR)
Platelet aggregation
c-Kit
NADPH-oxidase
DNA Methyltransferase
Monoamine Oxidase
S1P Receptor

Keywords