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Ginsenoside Rg5

Catalog No. T6S1487 CAS 186763-78-0

1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ameliorate lung inflammation possibly by inhibiting the binding of LPS to toll-like receptor (TLR)-4 on macrophages. 4. Ginsenoside Rg5 plays a novel role as an IGF-1R agonist, promoting therapeutic angiogenesis and improving hypertension without adverse effects in the vasculature. 5. Ginsenoside Rg5 blocks cell cycle of SK-HEP-1 cells at the Gl/S transition phase by down-regulating cyclin E-dependent kinase activity and that the down-regulation of cyclin E-dependent kinase activity is caused mainly by induced CDK2 inhibitor, p21Cip/WAF1 and decreased levels of cyclin E.

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Ginsenoside Rg5, CAS 186763-78-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 279.00
10 mg	In stock	$ 449.00
25 mg	In stock	$ 739.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 379.00

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Purity: 98%

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Description	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ameliorate lung inflammation possibly by inhibiting the binding of LPS to toll-like receptor (TLR)-4 on macrophages. 4. Ginsenoside Rg5 plays a novel role as an IGF-1R agonist, promoting therapeutic angiogenesis and improving hypertension without adverse effects in the vasculature. 5. Ginsenoside Rg5 blocks cell cycle of SK-HEP-1 cells at the Gl/S transition phase by down-regulating cyclin E-dependent kinase activity and that the down-regulation of cyclin E-dependent kinase activity is caused mainly by induced CDK2 inhibitor, p21Cip/WAF1 and decreased levels of cyclin E.
Targets&IC50	IGF-1:90 nM
Source	Natural Products > Araliaceae > Panax

Molecular Weight	767
Formula	C42H70O12
CAS No.	186763-78-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses[J]. International Immunopharmacology, 2014, 19(2):317-326.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Stem Cell Differentiation Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Tumor Natural Product Library

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Keywords

Ginsenoside Rg5 186763-78-0 Immunology/Inflammation Neuroscience NF-Κb Tyrosine Kinase/Adaptors NF-κB COX IGF-1R Nuclear factor-κB Inhibitor Cyclooxygenase Ginsenoside Rg 5 Nuclear factor-kappaB inhibit Ginsenoside Rg-5 inhibitor

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