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Pinoresinol

Catalog No. TN2080 CAS 487-36-5

Synonyms: (+)-Pinoresinol

Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1).

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Pinoresinol, CAS 487-36-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 287.00
25 mg	In stock	$ 489.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 969.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 98.67%

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Description	Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C.elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1).
In vitro	Six lignan standards [secoisolariciresinol diglucoside (SDG), secoisolariciresinol (SECO), Pinoresinol (PINO), lariciresinol, matairesinol (MAT), and hydroxymatairesinol] and their colonic metabolites [enterolactone (ENL) and enterodiol] were studied. First, differentiated cells were exposed to SDG, SECO, PINO, or ENL at increasing concentrations for 4 h, and their cellular contents (before and after deconjugation) were determined by HPLC. Second, in IL-1β-stimulated confluent and/or differentiated cells, lignan effects were tested on different soluble proinflammatory mediators quantified by enzyme immunoassays and on the NF-κB activation pathway by using cells transiently transfected. SECO, PINO, and ENL, but not SDG, were taken up and partly conjugated by cells, which is a saturable conjugation process. PINO was the most efficiently conjugated (75% of total in cells). In inflamed cells, PINO significantly reduced IL-6 by 65% and 30% in confluent and differentiated cells, respectively, and cyclooxygenase (COX)-2-derived prostaglandin E(2) by 62% in confluent cells. In contrast, MAT increased significantly COX-2-derived prostaglandin E(2) in confluent cells. Moreover, PINO dose-dependently decreased IL-6 and macrophage chemoattractant protein-1 secretions and NF-κB activity[1]
Source	Natural Products > Eucommiaceae > Eucommia

Synonyms	(+)-Pinoresinol
Molecular Weight	358.39
Formula	C20H22O6
CAS No.	487-36-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/ml (33.48 mM)

References and Literature

1. Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.J Nutr. 2012 Oct;142(10):1798-805.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Miao medicine Compound Library PBCRBS Traditional Chinese Medicine Compound Library Anti-Cancer Metabolism Compound Library Transcription Factor-Targeted Compound Library Immunology/Inflammation Compound Library Cell Cycle Compound Library Anti-Liver Cancer Compound Library Tibetan medicine Compound Library

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Keywords

Pinoresinol 487-36-5 Apoptosis Cell Cycle/Checkpoint NF-Κb NF-κB p53 CDK apoptotic sensitizer caterpillar inhibit (+)-Pinoresinol cancer Inhibitor lignol glioblastoma inhibitor

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