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Deoxyandrographolide

Catalog No. TQ0218 CAS 79233-15-1

Synonyms: 14-deoxyandrographolide

Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.

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Deoxyandrographolide, CAS 79233-15-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 189.00
5 mg	In stock	$ 396.00
10 mg	In stock	$ 572.00
25 mg	In stock	$ 883.00
50 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 448.00

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Purity: 99.67%

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Description	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.
In vitro	Treatment with 14-deoxyandrographolide (14-DAG) activated AMPK through induction of cyclic AMP-protein kinase A pathway [1]. 14-DAG down-regulated the formation of a death-inducing signaling complex, resulting in the desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway [2]. 14-DAG, in concentrations between 10-100 μM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAG reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) [3].
In vivo	The protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to the up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism [4].
Source	Natural Products > Acanthaceae > Andrographis

Synonyms	14-deoxyandrographolide
Molecular Weight	334.45
Formula	C20H30O4
CAS No.	79233-15-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (29.9 mM)

References and Literature

1. Arha D, et al. Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo. Eur J Pharmacol. 2015 Dec 5;768:207-16. 2. Xin XL, et al. Microbial transformation of deoxyandrographolide by Fusarium graminearum AS 3.4598. J Asian Nat Prod Res. 2011 Apr;13(4):350-5. 3. Deng S, et al. Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1615-8. 4. Xu Y, et al. Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities. Bioorg Med Chem. 2019;27(11):2209-2219.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Natural Product Library Immunology/Inflammation Compound Library Bioactive Compound Library RO5 Drug-like Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Anti-Tumor Natural Product Library NF-κB Signaling Compound Library Terpene Natural Product Library Natural Product Library for HTS

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Keywords

Deoxyandrographolide 79233-15-1 Apoptosis Immunology/Inflammation IL Receptor TNF Inhibitor proinflammatory mRNA inhibit LPS Interleukin Related neurite mediators outgrowth 14-deoxyandrographolide levels inhibitor

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