Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, which induces S6K pre-mRNA-selective splicing and subsequent inhibition of cell growth of multiple cancer cell types. cancer cell types cell growth.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 350.00 | |
5 mg | In stock | $ 970.00 | |
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, which induces S6K pre-mRNA-selective splicing and subsequent inhibition of cell growth of multiple cancer cell types. cancer cell types cell growth. |
Targets&IC50 | SRPK1:130 nM, SRPK3:260 nM, SRPK2:260 nM, CLK2:2.1 nM, CLK1:1.1 nM |
In vitro |
Exposure to CLK1/2-IN-3 (compound 3) at concentrations of 1.1-3.3 μM for 72 hours increases the expression of S6K mRNAs in MDA-MB-468 cells[1]. Significant reduction in the levels of endogenous phosphorylated SR proteins is observed with CLK1/2-IN-3 (5 μM)[1].Anti-proliferative activity is demonstrated by CLK1/2-IN-3 (1-10 μM) with GI50s of 3.4, 2.6, 2.1, 2.5, 2.2, 2.9, 1.5 μM for MDA-MB-468, A549, COLO205, HCT-116, NCI-H23, SW620, COLO320DM cells,respectively[1]. |
Synonyms | CLK1/2 inhibitor 3, CLK1/2-inhibitor-3, CLK1/2 IN 3, CLK1/2IN3 |
Molecular Weight | 375.42 |
Formula | C21H21N5O2 |
CAS No. | 1005784-60-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CLK1/2-IN-3 1005784-60-0 Cell Cycle/Checkpoint CDK CLK1/2 inhibitor 3 CLK1/2-inhibitor-3 CLK1/2 IN 3 CLK1/2IN3 CLK-1/2-IN-3 inhibitor inhibit