Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 313.00 | |
25 mg | In stock | $ 513.00 | |
50 mg | In stock | $ 690.00 | |
100 mg | In stock | $ 913.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 196.00 |
Description | OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. |
In vitro | OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. |
In vivo | OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease[1]. |
Molecular Weight | 463.28 |
Formula | C20H19Cl2F3N2O3 |
CAS No. | 1269826-44-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (23.74 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
OSBPL7-IN-1 1269826-44-9 Others OSBPL7 orally active ABCA1 OSBPL7 IN 1 Inhibitor OSBPL-7-IN-1 OSBPL7IN1 inhibit inhibitor