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OSBPL7-IN-1

Name: OSBPL7-IN-1
Brand: TargetMol
SKU: T9565
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9565Cas No. 1269826-44-9

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

OSBPL7-IN-1

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Purity: 99.73%

Catalog No. T9565Cas No. 1269826-44-9

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$513	In Stock	In Stock
50 mg	$690	In Stock	In Stock
100 mg	$913	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
In vitro	OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].
In vivo	OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease[1].

Chemical Properties

Molecular Weight	463.28
Formula	C₂₀H₁₉Cl₂F₃N₂O₃
Cas No.	1269826-44-9
Smiles	O[C@@H]1CCCC[C@H]1NC(=O)c1cnc(OCC(F)(F)F)c(c1)-c1ccc(Cl)c(Cl)c1
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (23.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (2.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1585 mL	10.7926 mL	21.5852 mL	107.9261 mL
5 mM	0.4317 mL	2.1585 mL	4.3170 mL	21.5852 mL
10 mM	0.2159 mL	1.0793 mL	2.1585 mL	10.7926 mL
20 mM	0.1079 mL	0.5396 mL	1.0793 mL	5.3963 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc