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Fudosteine

Catalog No. T1481 CAS 13189-98-5

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.

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Fudosteine, CAS 13189-98-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 50.00
50 mg	In stock	$ 65.00
100 mg	In stock	$ 117.00
200 mg	In stock	$ 173.00

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Purity: 99.81%

Biological Description

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Storage & Solubility Information

Description	Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.
In vitro	Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. Fudosteine (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. [1] Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. [2] Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [3] Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction. [4]
In vivo	Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats. [5]

Molecular Weight	179.24
Formula	C6H13NO3S
CAS No.	13189-98-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Osoata GO, et al. Chest, 2009, 135(6), 1513-1520. 2. Komatsu H, et al. Pulm Pharmacol Ther, 2005, 18(2), 121-127. 3. Rhee CK, et al. Eur Respir J, 2008, 32(5), 1195-1202. 4. Takahashi K, et al. Environ Toxicol Pharmacol, 2001, 10(3), 89-93. 5. Takahashi K, et al. Nihon Yakurigaku Zasshi, 2000, 116(6), 371-378.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library NO PAINS Compound Library Ferroptosis Compound Library Bioactive Compounds Library Max ReFRAME Related Library Bioactive Compound Library Orally Active Compound Library FDA-Approved & Pharmacopeia Drug Library Human Metabolite Library

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Keywords

Fudosteine 13189-98-5 Others mucoactive Inhibitor mRNA inhibit MUC5AC cysteine derivative inhibitor

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