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Enoxacin

Catalog No. T0717L CAS 74011-58-8

Synonyms: NSC 629661, AT 2266, Pd107779, CI 919

Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.

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Enoxacin, CAS 74011-58-8

Pack Size	Availability	Price/USD
25 mg	In stock	$ 34.00
50 mg	In stock	$ 45.00
100 mg	In stock	$ 63.00
500 mg	In stock	$ 129.00
1 g	In stock	$ 192.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.89%

Purity: 99.82%

Purity: 98.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.

In vitro

Enoxacin, a fluoroquinolone used as an antibacterial compound, enhances the production of miRNAs with tumor suppressor functions by binding to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP). [1] Enoxacin binds to the DNA active site and alters the breakage/reunion activity of the enzyme. Enoxacin stimulates cleavage of both relaxed and supercoiled forms of DNA in the absence of ATP, whereas CcdB induces cleavage only after many cycles of ATP-dependent breakage and reunion. [2] Enoxacin dose dependently reduces the number of osteoclasts differentiating in mouse marrow cultures stimulated with 1,25-dihydroxyvitamin D(3), as well as markers of osteoclast activity, and the number of resorption lacunae formed on bone slices. Enoxacin inhibits osteoclast formation at concentrations where osteoblast formation is not altered. [3] Enoxacin dose-dependently reduces the number of multinuclear cells expressing tartrate-resistant acid phosphatase (TRAP) activity produced by RANK-L-stimulated osteoclast precursors. Enoxacin directly inhibits osteoclast formation without affecting cell viability by a novel mechanism that involves changes in posttranslational processing and trafficking of several proteins with known roles in osteoclast function. [4] Enoxacin is able to decrease cell viability, induce apoptosis, cause cell cycle arrest, and inhibit the invasiveness of prostate cancer (PCa) cell lines. Enoxacin is also effective in restoring the global expression of miRNAs in prostate cancer (PCa) cell lines. [5]

Synonyms	NSC 629661, AT 2266, Pd107779, CI 919
Molecular Weight	320.32
Formula	C15H17FN4O3
CAS No.	74011-58-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 32 mg/mL (99.9 mM)

References and Literature

1. Sessa WC, et al. Proc Natl Acad Sci U S A,2011, 108(11), 4394-4399. 2. Scheirer KE, et al. J Biol Chem,1997, 272(43), 27202-27209. 3. Ostrov DA, et al. J Med Chem,2009, 52(16), 5144-5151. 4. Toro EJ, et al. J Biol Chem,2012, 287(21), 17894-17904. 5. Sousa E, et al. Epigenetics,2013, 8(5), 548-558.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-COVID-19 Compound Library Anti-Bacterial Compound Library ReFRAME Related Library Anti-Viral Compound Library

Related Products

Related compounds with same targets

NSC 617145 BMH-21 Fludarabine Phosphate Deoxycytidine triphosphate COH29 Butylparaben sodium Nedaplatin Procaine

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Enoxacin 74011-58-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis Topoisomerase Antibacterial Antibiotic gram-negative Bacterial DNA miRNA NSC 629661 AT 2266 inhibit Inhibitor mRNA CI-919 Pd107779 gram-positive CI 919 AT-2266 TAR-RNA siRNA NSC-629661 NSC629661 TRBP CI919 MicroRNA AT2266 gyrase topoisomerase inhibitor

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