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Abaperidone

Catalog No. T14083 CAS 183849-43-6

Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound that reduces basal hsp70 mRNA expression in rat striatum and prefrontal cortex. expression in the striatum and prefrontal cortex of rats.

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Abaperidone, CAS 183849-43-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Purity: 94.35%

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Description	Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound that reduces basal hsp70 mRNA expression in rat striatum and prefrontal cortex. expression in the striatum and prefrontal cortex of rats.
Targets&IC50	5-HT2A receptor:6.2 nM
In vitro	Abaperidone exhibits a strong binding affinity for dopamine D2 receptors, as well as a higher affinity for 5-HT2 receptors, with IC50 values of 17 and 6.2 nM, respectively.[1]
In vivo	After oral administration of either 0.5 mg/kg of Abaperidone or risperidone, the time course of the inhibition of climbing behavior for a period of several hours is tested in mice.[1] In a study of serum prolactin levels after oral administration of Abaperidone and haloperidol, the prolactin levels of risperidone at 5 mg/kg for either 1 or 3 days in rats, showing the prolactin levels increased in smaller than those for reference drugs. A lesser induction of catalepsy is observed for Abaperidone.[1]

Molecular Weight	452.47
Formula	C25H25FN2O5
CAS No.	183849-43-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bolós J, et al. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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U91356 PD-168077 maleate Domperidone (S)-Amisulpride JNJ-37822681 dihydrochloride (+)-PD 128907 hydrochloride Methiothepin mesylate ABT-670

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Keywords

Abaperidone 183849-43-6 GPCR/G Protein Neuroscience 5-HT Receptor Dopamine Receptor inhibitor inhibit

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