Search Result

Search Results for " erk-2 "

Targets

Compounds

Natural Products

305

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11225	ERK-IN-2		ERK
	ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].		ERK
T5535	ERK5-IN-2		ERK
	ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.		ERK
T8472	ERK1/2 inhibitor 2	ASTX-029,ASTX029	ERK
	ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.		ERK
T11226	ERK1/2 inhibitor 1		ERK
	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.		ERK
T9141	ERK-IN-3	ASN007 free base	ERK
	ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.		ERK
T14042	4-P-PDOT	4-phenyl-2- propionamidotetralin	Melatonin Receptor , MT Receptor
	4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.		Melatonin Receptor , MT Receptor
T72517	ERK-IN-2 free base
	ERK-IN-2 free base, an inhibitor of ERK2, demonstrates potent efficacy with an IC50 value of 1.8 nM. However, doses exceeding 10 μM may result in off-target toxicity and/or activity.
T27242	EF24	EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone	ERK , MEK , Caspase
	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ...		ERK , MEK , Caspase
T7506	Yoda 1		Piezo Channel
	Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)		Piezo Channel
T23046	N-tert-butyl-α-Phenylnitrone	(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide	ROS , COX
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge...		ROS , COX
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T11228	ERK2 IN-1		ERK
	ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.		ERK
T3166	VX-11e	Vertex-11e,VTX-11e,TCS ERK 11e	ERK , GSK-3 , FLT , CDK , Aurora Kinase
	VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.		ERK , GSK-3 , FLT , CDK , Aurora Kinase
T14894	CC-90003		ERK
	CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.		ERK
T11224	Rineterkib	ERK-IN-1	ERK , Raf
	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.		ERK , Raf
T4091	Temuterkib	LY3214996	ERK
	Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.		ERK
T14665L	Motixafortide TFA(664334-36-5,Free)	TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA	CXCR
	Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression...		CXCR
T7001	TIC10	ONC-201	Apoptosis , TNF
	TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.		Apoptosis , TNF
TP1904L	FSLLRY-NH2 TFA(245329-02-6 free base)		Protease-activated Receptor
	FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in iso...		Protease-activated Receptor
T6705	TIC10 Isomer	ONC201 isomer,TIC10 Analogue	Others
	TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv...		Others
T6511	Ravoxertinib	GDC-0994	ERK
	Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).		ERK
T9428	HM43239		FLT
	HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the k...		FLT
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T20759	XRP44X	XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras
	XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.		Ras
T8505	SC-236	Sc 236	Apoptosis , COX , PPAR
	SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).		Apoptosis , COX , PPAR
T36674	DMU-212		Apoptosis , ERK
	DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2...		Apoptosis , ERK
T7005L	Ulixertinib hydrochloride	Ulixertinib HCl,BVD-523,VRT752271,BVD 523,BVD523,VRT 752271
	Ulixertinib is an inhibitor of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits...
T63331	ERK1/2 inhibitor 8
	ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).
T39453	ERK-IN-3 benzenesulfonate
	ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK . ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancer...
T62933	ERK1/2 inhibitor 7
	ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).
T63708	Calpain-2-IN-1
	Calpain-2-IN-1 is a selective calpain-2 inhibitor that prolongs ERK activation and thus enhances learning and memory.
T79785	Laxiflorin B		ERK
	Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].		ERK
T73707	Insulin Detemir
	Insulin Detemir, an artificial insulin, effectively controls blood sugar levels by stimulating GLP-1 secretion through enhanced Gcg expression via the activation of Akt- and/or extracellular signal-regulated kinase (ERK)...
T63967	Multi-kinase-IN-2
	Multi-kinase-IN-2 is an orally active inhibitor of angiokinases. multi-kinase-IN-2 significantly inhibits the activity of angiokinases such as VEGFR-1/2/3, PDGFRα/β, FGFR-1, LYN and c-KIT kinases. -IN-2 significantly att...
T60509	Maprotiline
	Maprotiline inhibits cell proliferation and metastasis with anticancer effects. Maprotiline induces apoptosis in cancer cells by targeting ERK signaling pathway and CRABP1. Maprotiline is a highly selective norepinephrin...
T62752	KRAS inhibitor-16
	KRAS inhibitor-16 (compound 3-11) is a potent inhibitor of KRAS G12C (IC50: 0.457 μM). KRAS inhibitor-16 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 3.06, 11.1 μM respectively. KRAS inhibitor-16 has...
T74782	CXJ-2		PI3K
	CXJ-2, a cyclic peptide, demonstrates moderate affinity for elastin-derived peptides (EDPs) and exhibits potent inhibition of the PI3K/ERK pathway, alongside significant reduction in hepatic stellate cell proliferation a...		PI3K
T74373	ERK1/2 inhibitor 3
	ERK1/2 Inhibitor 3, a potent inhibitor of ERK1/2, plays a crucial role in the signal transduction pathway by targeting the Mitogen-activated protein kinase (MAPK) family, specifically the extracellular signal-regulated k...
T74374	ERK1/2 inhibitor 4
	ERK1/2 Inhibitor 5, a potent suppressant of the ERK1/2 pathway, is instrumental in the mitogen-activated protein kinase (MAPK) signal transduction pathway, where extracellular signal-regulated kinase (ERK) serves as a cr...
T63235	KRAS inhibitor-14
	KRAS inhibitor-14 is a potent inhibitor of KRAS G12C (IC50: 0.249 μM). KRAS inhibitor-14 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 1.12, >33.3 μM, respectively. KRAS inhibitor-14 has potential to...
T62784	KRAS inhibitor-18
	KRAS inhibitor-18 (compound 3-10) is a potent inhibitor of KRAS G12C (IC50: 4.74 μM). KRAS inhibitor-18 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 66.4, 11.1 μM respectively. KRAS inhibitor-18 has...
T78190	ERK1/2 inhibitor 9		ERK
	ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the reduction of phospho-ERK1/2 levels. When conjugated with trans-cy...		ERK
T79808	KRAS G12C inhibitor 61		ERK
	KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM. This inhibitor is applicable in the research of pancreatic, colorecta...		ERK
T62981	KRAS inhibitor-17
	KRAS inhibitor-17 (compound 3-9) is a potent inhibitor of KRAS G12C (IC50: 3.37 μM). KRAS inhibitor-17 exhibits p-ERK inhibition with IC50 = 9.25 μM in MIA PaCA-2 cells and >33.3 μM in A549 cells. KRAS inhibitor-17 has t...
T62737	KRAS inhibitor-15
	KRAS inhibitor-15 (compound 3-19) is a potent inhibitor of KRAS G12C (IC50: 0.954 μM). KRAS inhibitor-15 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 2.03, >33.3 μM, respectively. KRAS inhibitor-15 h...
T80548	MSIRK		ERK
	mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 μM. It disrupts the interaction between the α and βγ subunits, facilitating α subunit dissociation without inducing nucl...		ERK
T68267	RO5068760
	RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen...
T63164	KRAS inhibitor-13
	KRAS inhibitor-13 (compound 5-6) is a potent inhibitor of KRAS G12C (IC50: 0.883 μM). KRAS inhibitor-13 has a p-ERK inhibitory effect in MIA PaCA-2, A549 cells with IC50 values of 5.9 and >100 μM respectively. KRAS inhib...
T62751	KRAS inhibitor-12
	KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM). KRAS inhibitor-12 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50 values of 1.3, 3.7 μM respectively. KRAS inhibitor-12 ...
T63863	KRAS G12C inhibitor 47
	KRAS G12C inhibitor 47 is a potent inhibitor of KRAS G12C (IC50: 0.172 μM). KRAS G12C inhibitor 47 exhibits p-ERK inhibition in MIA PaCA-2 cells, A549 cells with IC50 values of 0.046 μM and 69.8 μM respectively. KRAS G12...

Compounds

Synonym: ASTX-029,ASTX029

Synonym: ASN007 free base

Target: ERK

4-P-PDOT

T14042

Synonym: 4-phenyl-2- propionamidotetralin

Target: Melatonin Receptor, MT Receptor

Synonym: EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

Target: ERK, MEK, Caspase

Yoda 1

T7506

Synonym:

Target: Piezo Channel

N-tert-butyl-α-Phenylnitrone

T23046

Synonym: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

Target: S1P Receptor, LPL Receptor

Synonym: Vertex-11e,VTX-11e,TCS ERK 11e

Target: ERK, GSK-3, FLT, CDK, Aurora Kinase

Motixafortide TFA(664334-36-5,Free)

T14665L

Synonym: TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA

Target: Apoptosis, TNF

FSLLRY-NH2 TFA(245329-02-6 free base)

TP1904L

Synonym:

Target: Protease-activated Receptor

TIC10 Isomer

T6705

Synonym: ONC201 isomer,TIC10 Analogue

Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

XRP44X

T20759

Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Target: Apoptosis, COX, PPAR

DMU-212

T36674

Synonym:

Target: Apoptosis, ERK

Ulixertinib hydrochloride

T7005L

Synonym: Ulixertinib HCl,BVD-523,VRT752271,BVD 523,BVD523,VRT 752271

ERK-IN-3 benzenesulfonate

KRAS G12C inhibitor 61

KRAS G12C inhibitor 47

T63863

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
TN3967	Epieriocalyxin A		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
TCS2170	2,5-Dihydroxyacetophenone	Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP	ERK , NF-κB , Tyrosinase
	1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...		ERK , NF-κB , Tyrosinase
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T5S0168	Atractylenolide II	2-Atractylenolide,Asterolide	Apoptosis , ERK , p38 MAPK , Akt , STAT
	1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.		Apoptosis , ERK , p38 MAPK , Akt , STAT
T5727	CAFESTOL		ERK , NF-κB , COX , PGE Synthase
	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...		ERK , NF-κB , COX , PGE Synthase
T2845	Imperatorin	Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen	TRP/TRPV Channel , AChR , AChE , NOD
	Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.		TRP/TRPV Channel , AChR , AChE , NOD
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
T5S0890	Oleandrin	Neriostene,Folinerin,Foliandrin	Apoptosis , ATPase , Potassium Channel , Sodium Channel
	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ...		Apoptosis , ATPase , Potassium Channel , Sodium Channel
TN1557	Decursinol angelate		ERK , VEGFR , PKC , JNK
	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an...		ERK , VEGFR , PKC , JNK
T3822	Bellidifolin	Bellidifoline,Bellidifolium	Others , HIV Protease
	Bellidifolin (Bellidifoline) has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms rela...		Others , HIV Protease
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T6S0525	Farrerol		ERK , p38 MAPK , Akt
	1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3....		ERK , p38 MAPK , Akt
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
T5S1982	Periplocin	Periplocoside	Apoptosis , Others
	1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato...		Apoptosis , Others
T2940	6-Hydroxyflavone	6-HF	GABA Receptor
	6-Hydroxyflavone (6-HF) is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India). 6-Hydro...		GABA Receptor
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin

Natural Products

Epieriocalyxin A

TN3967

Synonym:

Target: ERK, BCL, ROS, Caspase, DNA/RNA Synthesis, JNK

2,5-Dihydroxyacetophenone

TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP

Target: ERK, NF-κB, Tyrosinase

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Atractylenolide II

T5S0168

Synonym: 2-Atractylenolide,Asterolide

Target: Apoptosis, ERK, p38 MAPK, Akt, STAT

CAFESTOL

T5727

Synonym:

Target: ERK, NF-κB, COX, PGE Synthase

Imperatorin

T2845

Synonym: Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen

Target: TRP/TRPV Channel, AChR, AChE, NOD

Hypericin

T6S0923

Synonym: Hypericine,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Synonym: Neriostene,Folinerin,Foliandrin

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

Decursinol angelate

TN1557

Synonym:

Target: ERK, VEGFR, PKC, JNK

Bellidifolin

T3822

Synonym: Bellidifoline,Bellidifolium

Target: Others, HIV Protease

β,β-Dimethylacrylshikonin

T3S2344

Synonym: Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Farrerol

T6S0525

Synonym:

Target: ERK, p38 MAPK, Akt

Prunetin

T4S0878

Synonym: Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Periplocin

T5S1982

Synonym: Periplocoside

Target: Apoptosis, Others

6-Hydroxyflavone

T2940

Synonym: 6-HF

Target: GABA Receptor

Mulberroside A

T6S1597

Synonym:

Target: TNF, Tyrosinase, Interleukin

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04539	ERK2 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 67 kDa and the accession number is P28482-1.
TMPY-04571	ERK2 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus Insect Cells
	ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.1 kDa and the accession number is P63085.
TMPY-04544	MEK2 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/...
TMPY-04412	Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein,...
TMPH-03265	CMKLR2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His)	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate...
TMPJ-01125	PEA15 Protein, Human, Recombinant	Human	E. coli
	Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis...
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP)	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph...
TMPY-04466	STK40 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to...
TMPY-02519	BLVRB Protein, Human, Recombinant (His)	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann...
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPY-00849	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.
TMPY-02358	CD98 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CD98 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P10852-2.
TMPY-00871	LAYN Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LAYN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q6UX15-2.
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293 Cells
	FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149)	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2.
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293 Cells
	Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
TMPY-00850	ST2/IL-1 RL1 Protein, Human, Recombinant	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293 Cells
	Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	HEK293 Cells
	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
TMPY-01985	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
TMPY-05427	CD19 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2.
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a)	Human	E. coli
	SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
TMPJ-00335	TGFBR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
TMPY-02096	TACI Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2.
TMPY-01935	C-Kit Protein, Human, Recombinant (His)	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.
TMPY-02367	Neuropilin-1 Protein, Human, Recombinant (isoform b, His)	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2.
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-01359	ST2/IL-1 RL1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2.
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2.
TMPY-04844	BTN3A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.
TMPY-01199	CD74 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-05586	CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-04829	G-CSF Protein, Human, Recombinant	Human	HEK293 Cells
	G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-01871	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)	Human	HEK293 Cells
	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
TMPY-01442	DMBT1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d...
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His)	Human	E. coli
	KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2.
TMPY-03425	Tau Protein, Human, Recombinant (His)	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are...
TMPY-02500	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2.
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His)	Human	E. coli
	KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2.
TMPY-02432	VEGF164 Protein, Rat, Recombinant	Rat	Baculovirus Insect Cells
	VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2.
TMPY-02231	TrkB Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2.
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