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Epieriocalyxin A

Catalog No. TN3967 CAS 191545-24-1

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.

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Epieriocalyxin A, CAS 191545-24-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 216.00
5 mg	Inquiry	$ 441.00
10 mg	Inquiry	$ 662.00

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Purity: 97.00%

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Description	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
In vitro	Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. EpiA induced annexin V flipping in the cell membrane and DNA fragment. We also showed that EpiA induced the generation of ROS in cells, as well as damage of the mitochondrial membrane. Western blot results showed that both JNK and ERK1/2 activation was decreased after EpiA treatment in a dose-dependent manner. EpiA increased the expression of caspase 3 and Bax and decreased Bcl2 expression.
Source	Natural Products > Lamiaceae > Isodon

Molecular Weight	344.4
Formula	C20H24O5
CAS No.	191545-24-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. Cell Biochem Biophys. 2015 Nov;73(2):559-564.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Rare Natural Compound Library

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Keywords

Epieriocalyxin A 191545-24-1 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Immunology/Inflammation MAPK Proteases/Proteasome JNK DNA/RNA Synthesis BCL ERK ROS Caspase diterpenoid Extracellular signal regulated kinases colon cancer ERK1/2 epi-Eriocalyxin A inhibit Inhibitor Bcl-2 inhibitor

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