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Ravoxertinib

Name: Ravoxertinib
Brand: TargetMol
SKU: T6511
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6511Cas No. 1453848-26-4

Alias GDC-0994

Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM.

Ravoxertinib

🥰Excellent

Purity: 99.87%

Catalog No. T6511Alias GDC-0994Cas No. 1453848-26-4

Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$77	In Stock
10 mg	$97	In Stock
25 mg	$176	In Stock
50 mg	$297	In Stock
100 mg	$443	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

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Batch Information

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Purity:99.87%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM.
Targets&IC50	ERK1:1.1 nM, ERK2:0.3 nM, p-RSK:12 nM
In vitro	GDC-0994 significantly inhibits phospho-p90RSK in tumor cells.
In vivo	GDC-0994 (p.o.) inhibits intracellular ERK phosphorylation and activation of ERK-mediated signaling pathways, subsequently impeding the proliferation and survival of ERK-dependent tumor cells. In in vitro cancer models, GDC-0994 (p.o.) demonstrates significant single-dose efficacy, including against BRAF and KRAS mutant human xenograft tumors in mice.
Synonyms	GDC-0994

Chemical Properties

Molecular Weight	440.86
Formula	C₂₁H₁₈ClFN₆O₂
Cas No.	1453848-26-4
Smiles	Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 81 mg/mL (183.73 mM), Sonication is recommended.

DMSO: 81 mg/mL (183.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2683 mL	11.3415 mL	22.6829 mL	113.4147 mL
5 mM	0.4537 mL	2.2683 mL	4.5366 mL	22.6829 mL
10 mM	0.2268 mL	1.1341 mL	2.2683 mL	11.3415 mL
20 mM	0.1134 mL	0.5671 mL	1.1341 mL	5.6707 mL
50 mM	0.0454 mL	0.2268 mL	0.4537 mL	2.2683 mL
100 mM	0.0227 mL	0.1134 mL	0.2268 mL	1.1341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc