Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
5 mg | In stock | $ 126.00 | |
10 mg | In stock | $ 183.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 486.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 127.00 |
Description | ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations. |
In vitro | ERK-IN-3 shows single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines.ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates like RSK1, FRA1, and Elk1 in various cell lines. |
In vivo | ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice that was well tolerated at efficacious doses. |
Synonyms | ASN007 free base |
Molecular Weight | 473.93 |
Formula | C22H25ClFN7O2 |
CAS No. | 2055597-12-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (527.50 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ERK-IN-3 2055597-12-9 MAPK ERK ERK1/2 inhibit Inhibitor ASN 007 ERK IN 3 RAS ASN-007 Extracellular signal regulated kinases cancer ASN007 free base ASN007 ERKIN3 inhibitor