Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 76.00 | |
5 mg | In stock | $ 153.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 436.00 | |
50 mg | In stock | $ 643.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 148.00 |
Description | SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling. |
Targets&IC50 | S1P1:13.8 nM (EC50) |
Synonyms | SEW2871 |
Molecular Weight | 440.36 |
Formula | C20H10F6N2OS |
CAS No. | 256414-75-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8.8 mg/mL(20 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SEW2871 256414-75-2 GPCR/G Protein LPL Receptor S1P Receptor Alzheimer’s disease Crohn's disease Lysophospholipid Receptor Akt SEW?2871 Protein kinase B orally active PKB diabetes inhibit colitis Extracellular signal regulated kinases SEW-2871 ischaemia-reperfusion injury SEW 2871 SEW2871 liver fibrosis ERK LX-2 cells Inhibitor inhibitor