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Prunetin

Catalog No. T4S0878   CAS 552-59-0
Synonyms: Prunusetin

1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.

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Prunetin Chemical Structure
Prunetin, CAS 552-59-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
5 mg In stock $ 89.00
10 mg In stock $ 155.00
25 mg In stock $ 263.00
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1 mL * 10 mM (in DMSO) In stock $ 87.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
Source
Synonyms Prunusetin
Molecular Weight 284.26
Formula C16H12O5
CAS No. 552-59-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (175.9 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

TargetMolReferences and Literature

1. Yang G , Ham I , Choi H Y . Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway[J]. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association, 2013, 58:124-132.

Related compound libraries

This product is contained In the following compound libraries:
The Yao nationality medicine Library Traditional Chinese Medicine Monomer Library Anti-Prostate Cancer Compound Library NO PAINS Compound Library NF-κB Signaling Compound Library Anti-Tumor Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Reprogramming Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library

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Keywords

Prunetin 552-59-0 MAPK Metabolism NF-Κb ERK Dehydrogenase NF-κB allosteric Aldehyde Dehydrogenase (ALDH) inflammatory Inhibitor liver epithelial nasal allergic Prunusetin inhibit rhinitis cytokine inhibitor

 

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