Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 153.00 | |
5 mg | In stock | $ 389.00 | |
10 mg | In stock | $ 569.00 | |
25 mg | In stock | $ 882.00 | |
50 mg | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 348.00 |
Description | Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells. |
In vitro | toddaculin displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents[1]. |
Source |
Molecular Weight | 274.31 |
Formula | C16H18O4 |
CAS No. | 4335-12-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (200.51 mM)
You can also refer to dose conversion for different animals. More
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Toddaculin 4335-12-0 Others inhibit osteoclast Inhibitor differentiation leukemic Apoptosis osteoblast anti-inflammatory coumarin inhibitor