Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Acetylsalicylic acid also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.
Description | Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Acetylsalicylic acid also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively. |
Targets&IC50 | COX-1:5μg/mL, COX-2:210 μg/mL |
Cell Research | Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5]. |
Synonyms | 阿司匹林, Acetylsalicylic Acid, ASA, 邻乙酰水杨酸, Acetylsalicylate |
Molecular Weight | 180.159 |
Formula | C9H8O4 |
CAS No. | 50-78-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 18 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Aspirin 50-78-2 免疫与炎症 神经科学 微生物学 自噬 Autophagy COX Mitophagy Virus Protease Nuclear factor-κB inhibit Inhibitor Cyclooxygenase Mitochondrial Autophagy NF-κB Nuclear factor-kappaB Antipyretic effect fever ASA cerebrovascular thrombosis Acetylsalicylic Acid prostaglandin synthetase p38 MAPK inflammation coronary artery Caspase platelet cancer Acetylsalicylate Apoptosis inhibitor