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Aspirin

Catalog No. T0005 CAS 50-78-2

Synonyms: Acetylsalicylic Acid, ASA, Acetylsalicylate

Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Acetylsalicylic acid also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.

Aspirin, CAS 50-78-2

Pack Size	Availability	Price/USD
50 mg	In stock	28.00
100 mg	In stock	35.00
200 mg	In stock	42.00
500 mg	In stock	50.00
1 g	In stock	59.00
1 mL * 10 mM (in DMSO)	In stock	54.00

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Purity 98.98%

HNMR HPLC COA Datasheet MSDS

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Description	Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Acetylsalicylic acid also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.
Targets&IC50	COX-1 : ic50 5μg/mL, COX-2 : ic50 210μg/mL,
Cell Research	Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5].

Synonyms	Acetylsalicylic Acid , ASA , Acetylsalicylate
Purity	98.98%
Molecular Weight	180.16
Formula	C9H8O4
CAS No.	50-78-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 18 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

4% DMSO+PBS: 10mg/mL

Citations

References and Literature

1. Kopp E, et al. Science, 1994, 265(5174), 956-959.

Related compound libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Autophagy Compound Library Neuronal Signaling Compound Library Protease Inhibitor Library FDA-approved Drug Library Immunology/Inflammation Compound Library CNS-Penetrant Compound Library

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