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Aspirin

Catalog No. T0005   CAS 50-78-2
Synonyms: 阿司匹林, Acetylsalicylic Acid, ASA, 邻乙酰水杨酸, Acetylsalicylate

Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Acetylsalicylic acid also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.

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Aspirin, CAS 50-78-2
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Acetylsalicylic acid also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.
Targets&IC50 COX-1:5μg/mL, COX-2:210 μg/mL
Cell Research Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5].
Synonyms 阿司匹林, Acetylsalicylic Acid, ASA, 邻乙酰水杨酸, Acetylsalicylate
Molecular Weight 180.159
Formula C9H8O4
CAS No. 50-78-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 18 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kopp E, et al. Science, 1994, 265(5174), 956-959.

Citations

1. Bi X, Yan X, Jiang B, et al. Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses. Toxicology and Applied Pharmacology. 2021: 115778.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Autophagy Compound Library HIF-1 Signaling Pathway Compound Library Anti-Cardiovascular Disease Compound Library Anti-Obesity Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library

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Salinomycin sodium salt Physalin A Latifolin Lup-20(29)-en-28-oic acid R1487 Hydrochloride PTC-209 hydrobromide LYN-1604 ALLO-1

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Keywords

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