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Aspirin

Catalog No. T0005   CAS 50-78-2
Synonyms: Acetylsalicylate, Acetylsalicylic Acid, ASA

Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Aspirin also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.

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Aspirin Chemical Structure
Aspirin, CAS 50-78-2
Pack Size Availability Price/USD Quantity
200 mg In stock $ 31.00
500 mg In stock $ 46.00
1 g In stock $ 53.00
5 g In stock $ 87.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring COX-1. Aspirin also inhibits the expression of COX-2 in HUVEC and neonatal rat ventricular cardiomyocytes, and then reduce PG production and the down-regulation of ERK and NF-KB, respectively.
Targets&IC50 COX-2:210 μg/mL, COX-1:5μg/mL
Cell Research Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5].
Synonyms Acetylsalicylate, Acetylsalicylic Acid, ASA
Molecular Weight 180.16
Formula C9H8O4
CAS No. 50-78-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (277.53 mM)

TargetMolReferences and Literature

1. Kopp E, et al. Science, 1994, 265(5174), 956-959.

TargetMolCitations

1. Bi X, Yan X, Jiang B, et al. Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses. Toxicology and Applied Pharmacology. 2021: 115778. 2. Liu Z, Tan S, Zhou L, et al.SCGN deficiency is a risk factor for autism spectrum disorder.Signal Transduction and Targeted Therapy.2023, 8(1): 1-15.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Natural Product Library for HTS Inhibitor Library Natural Product Library Highly Selective Inhibitor Library Drug Repurposing Compound Library Traditional Chinese Medicine Monomer Library Anti-Cancer Clinical Compound Library

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Keywords

Aspirin 50-78-2 Autophagy Immunology/Inflammation Microbiology/Virology Neuroscience COX Mitophagy Virus Protease Nuclear factor-κB inhibit Inhibitor Cyclooxygenase Mitochondrial Autophagy NF-κB Nuclear factor-kappaB Antipyretic effect fever cerebrovascular thrombosis prostaglandin synthetase p38 MAPK inflammation coronary artery Acetylsalicylate Caspase Acetylsalicylic Acid platelet cancer ASA Apoptosis inhibitor

 

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