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SC-236

Catalog No. T8505 CAS 170569-86-5

Synonyms: Sc 236

SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).

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SC-236, CAS 170569-86-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 207.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 77.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).
Targets&IC50	COX-2:0.005 μM , COX-1:17.8 μM
In vivo	SC-236 protects against cartilage damage in addition to reducing inflammation and pain for those with osteoarthritis

Synonyms	Sc 236
Molecular Weight	401.79
Formula	C16H11ClF3N3O2S
CAS No.	170569-86-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (56 mM)

References and Literature

1. Kim S J , Jeong H J , Moon P D , et al. The COX-2 inhibitor SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model[J]. Life Sciences, 2007, 81(11):0-872.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Anti-Colorectal Cancer Compound Library Neuronal Signaling Compound Library Pyroptosis Compound Library NO PAINS Compound Library Transcription Factor-Targeted Compound Library Anti-Breast Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SC-236 170569-86-5 Apoptosis DNA Damage/DNA Repair Immunology/Inflammation Metabolism Neuroscience COX PPAR SC 236 gastric Sc 236 cancer ischemia Liver SC236 inhibit allodynia Inhibitor fibrogenesis neuroprotection Cyclooxygenase TNF-α Peroxisome proliferator-activated receptors fibrosis inhibitor

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