Search Result

Search Results for " atr "

Targets

294

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T3032	VE-821	ATR Inhibitor IV	ATM/ATR
	VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).		ATM/ATR
T62083	Camonsertib	ATR inhibitor 4,RP-3500	ATM/ATR
	Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...		ATM/ATR
T40077	ATR-IN-9
	ATR-IN-9 is a highly effective inhibitor of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). With an IC50 value as low as 10 nM, ATR-IN-9 demonstrates exceptional potency.
T40212	ATR-IN-4
	ATR-IN-4, a potent inhibitor of ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase), restricts the growth of DU145 prostate cancer cells and NCI-H460 lung cancer cells, with IC 50 values of 130.9 nM and 41.3...
T9321	Zapnometinib	ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid	Influenza Virus , MEK , Antibacterial
	Zapnometinib (ATR-002) is a MEK inhibitor.		Influenza Virus , MEK , Antibacterial
T62035	ATR-IN-7
	ATR-IN-7 is a potent inhibitor of ATR.
T61636	ATR-IN-19
	ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].
T63555	ATR-IN-6
	ATR-IN-6 is a potent inhibitor of ATR. ATR is a protein kinase that is involved in genome stability and DNA damage repair and is a member of the PIKK family. aTR-IN-6 has shown potential for ATR kinase-mediated diseases ...
T62651	ATR-IN-11
	ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinases. ATR-IN-11 is a promising lead compound for the discovery of subsequent drugs targeting the ATR kinase, a key regulator...
T61587	ATR-IN-15
	ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cell...
T79058	ATR-IN-24		ATM/ATR
	ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].		ATM/ATR
T63923	ATR-IN-5
	ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair. ATR is a member of the PIKK family, a class of protein kinases involved in genome stabili...
T62233	ATR-IN-10
	ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).
T62548	ATR-IN-17
	ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).
T61432	ATR-IN-16
	ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1].
T79121	ATR-IN-29		ATM/ATR
	ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].		ATM/ATR
T79031	ATR-IN-21		ATM/ATR
	ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].		ATM/ATR
T63604	ATR-IN-18
	ATR-IN-18 is an orally active ATR kinase inhibitor (IC50: 0.69 nM). aTR-IN-18 exhibited anti-proliferative effects in LoVo cells (IC50: 37.34 nM). aTR-IN-18 showed anti-tumor effects.
T62084	ATR-IN-8
	ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.
T63066	ATR-IN-13
	ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).
T61808	ATR-IN-14
	ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, demonstrating a remarkable inhibition rate of 98.03% at 25 nM. Moreover...
T62563	ATR-IN-12
	ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia capillaris and Rad3-related (ATR) kinase (IC50: 0.007 μM). ATR-IN-12 is a promising lead compound for subsequent drug discovery studies on ATR kinases.
T73301	ATR-IN-20
	ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3Kα (100 nM), ATM (100 nM), and DNA-PK...
T79033	ATR-IN-22		ATM/ATR
	ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and demonstrates anti-tumor activity in colon cancer [1].		ATM/ATR
T78959	ATR-IN-23		ATM/ATR
	ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ...		ATM/ATR
T12225	Nevanimibe	ATR-101,PD-132301	Others
	Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).		Others
T10407	Gartisertib	ATR inhibitor 2	ATM/ATR
	ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylati...		ATM/ATR
T12225L	Nevanimibe hydrochloride	PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis , Acyltransferase
	Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).		Apoptosis , Acyltransferase
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T3338	Ceralasertib	AZD6738	ATM/ATR
	Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.		ATM/ATR
T5175	Azd1390		ATM/ATR
	AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.		ATM/ATR
T1958	AZ20		ATM/ATR , mTOR
	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.		ATM/ATR , mTOR
T4443	AZ32		ATM/ATR
	AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.		ATM/ATR
T6770	AZD0156		Apoptosis , ATM/ATR
	AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.		Apoptosis , ATM/ATR
T1923	BRD4770		Histone Methyltransferase
	BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.		Histone Methyltransferase
T1821	CGK733	CGK 733	ATM/ATR
	CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.		ATM/ATR
T6261	CP-466722	CP 466722,CP466722	ATM/ATR
	CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.		ATM/ATR
T2084	ETP-46464		ATM/ATR , DNA-PK , PI3K , mTOR
	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).		ATM/ATR , DNA-PK , PI3K , mTOR
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T7318	Elimusertib	BAY-1895344	ATM/ATR
	Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...		ATM/ATR
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T5626	Atrazine	Aktikon,Chromozin,Gesaprim,Oleogesaprim	Others
	Atrazine (Oleogesaprim) is an herbicide that does not occur naturally,and is a selective triazine herbicide. Atrazine (Oleogesaprim) is also a potent endocrine disruptor.		Others
T7221	Satraplatin	BMS182751,JM216,BMY45594	DNA Alkylator/Crosslinker , DNA Alkylation
	Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.		DNA Alkylator/Crosslinker , DNA Alkylation
T12015	Methyl homoveratrate		Others
	Methyl homoveratrate, a McN5691 (RWJ-26240) metabolite detected in vivo in plasma, urine, and fecal extracts, functions as a voltage-sensitive calcium channel blocker.		Others
T39392L	C-Type Natriuretic Peptide (CNP) (1-22), human acetate	C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)	Others
	C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), huma...		Others
T5642	Tegatrabetan	BC2059	Wnt/beta-catenin
	Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.		Wnt/beta-catenin
T2495	Lomeguatrib	PaTrin-2	DNA Methyltransferase , DNA Alkylation
	Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .		DNA Methyltransferase , DNA Alkylation
TP2359	FMOC-DL-7-AZATRYPTOPHAN	2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{1H-pyrrolo[2,3-b]pyridin-3-yl}propanoic acid	Others
	FMOC-DL-7-AZATRYPTOPHAN (2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{1H-pyrrolo[2,3-b]pyridin-3-yl}propanoic acid) is a peptide		Others
T0155	Argatroban	MCI-9038,MD-805,Argipidine	Thrombin
	Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.		Thrombin

Compounds

Tuvusertib

T10406

Synonym: M1774,ATR inhibitor 1

Target: Apoptosis, ATM/ATR, Others, Chk

VE-821

T3032

Synonym: ATR Inhibitor IV

Target: ATM/ATR

Camonsertib

T62083

Synonym: ATR inhibitor 4,RP-3500

Synonym: ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Target: Influenza Virus, MEK, Antibacterial

Synonym: ATR-101,PD-132301

Target: Others

Gartisertib

T10407

Synonym: ATR inhibitor 2

Target: ATM/ATR

Nevanimibe hydrochloride

T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

NU6027

T6612

Synonym:

Target: ATM/ATR, DNA-PK, CDK

Target: ATM/ATR, mTOR

Target: Apoptosis, ATM/ATR

BRD4770

T1923

Synonym:

Target: Histone Methyltransferase

Synonym: CP 466722,CP466722

Target: ATM/ATR, DNA-PK, PI3K, mTOR

KU-55933

T2685

Synonym: ATM Kinase Inhibitor

Target: ATM/ATR, DNA-PK, PI3K, mTOR, Autophagy

Synonym: Aktikon,Chromozin,Gesaprim,Oleogesaprim

Target: Others

Satraplatin

T7221

Synonym: BMS182751,JM216,BMY45594

Target: DNA Alkylator/Crosslinker, DNA Alkylation

C-Type Natriuretic Peptide (CNP) (1-22), human acetate

T39392L

Synonym: C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)

Target: Wnt/beta-catenin

Lomeguatrib

T2495

Synonym: PaTrin-2

Target: DNA Methyltransferase, DNA Alkylation

FMOC-DL-7-AZATRYPTOPHAN

TP2359

Synonym: 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{1H-pyrrolo[2,3-b]pyridin-3-yl}propanoic acid

Target: Others

Argatroban

T0155

Synonym: MCI-9038,MD-805,Argipidine

Target: Thrombin

Cat No.	Product Name	Synonyms	Targets
TN1673	Garcinone C		ATM/ATR , CDK , STAT , AChR , Antifection
	Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe...		ATM/ATR , CDK , STAT , AChR , Antifection
T3330	Trans-Trimethoxyresveratrol	trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene	Reactive Oxygen Species
	trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy...		Reactive Oxygen Species
T3902	Atractylenolide III	ICodonolactone,8β-Hydroxyasterolide	Apoptosis
	Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung...		Apoptosis
T6S1010	Allomatrine		Others
	Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord.		Others
TN1640	Fabiatrin		Others
	Fabiatrin is a natural product isolated and identified from n-butanol extract of Przewalskia tangutica.		Others
T3666	Atractylodin	Atractydin	Lipid
	Atractylodin (Atractydin) has high lipase inhibitory activity (IC5:39.12 μM); Atractylodin possesses strong repellency activities against T. castaneum adults (LD50: 1.83 μg/cm). The repellency of Atractylodin (0.63 μg/cm...		Lipid
T2810	(20S)-Protopanaxatriol	20(S)-APPT,g-PPT	Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor
	(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
TCS1372	Atraric acid		Phosphatase , Androgen Receptor
	Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases. It inhibits PTP1B activity in a dose-depen...		Phosphatase , Androgen Receptor
T5S0168	Atractylenolide II	2-Atractylenolide,Asterolide	Apoptosis , ERK , p38 MAPK , Akt , STAT
	1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.		Apoptosis , ERK , p38 MAPK , Akt , STAT
T3744	Veratric acid	Veratrumenoic acid,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species , COX
	Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.		Reactive Oxygen Species , COX
T2754	Oxymatrine	Oxysophoridine,Matrine N-oxide	Influenza Virus , Autophagy , TGF-beta/Smad
	Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.It can also inhibit iNOS expressio...		Influenza Virus , Autophagy , TGF-beta/Smad
T8170	Carboxyatractyloside	Gummiferin,Carboxyatractyloside tripotassium salt	Others
	Carboxyatractyloside (Carboxyatractyloside tripotassium salt) is a natural product. It acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.		Others
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T3791	Atractyloside A		AChR
	Atractyloside is a glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of adenine nucleotide tra...		AChR
T3S0156	Atractyloside potassium salt	Atractyloside Dipotassium Salt	Others
	1. Atractyloside potassium salt (Atractyloside Dipotassium Salt) inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane.		Others
T3364	Veratramine	NSC17821,NSC23880	Sodium Channel
	Veratramine (NSC-23880)(NSC-17821; NSC-23880) is a potent signal transduction inhibitor for treating tumors.		Sodium Channel
T3S1068	Oxyresveratrol	trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene	Tyrosinase , Autophagy , HSV
	1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid...		Tyrosinase , Autophagy , HSV
T0657	Veratryl alcohol	3,4-Dimethoxybenzyl alcohol	Others
	Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi. It is usually used as a non-phenolic substrate for the determination of ligninolytic activity.		Others
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide	(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14	Wnt/beta-catenin
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa...		Wnt/beta-catenin
TN3340	Acetylatractylodinol	Tractylodinol acetate	Others
	Acetylatractylodinol (Tractylodinol acetate) is a natural product isolated from Atractylodes lancea, possesses antioxidant activity.		Others
T3917	Protopanaxatriol	20(R)-APPT,20(R)-Protopanaxatriol,(20R)-Protopanaxatriol	PPAR
	Protopanaxatriol (20(R)-APPT), a major ginseng constituent, is a novel PPARγ antagonist.		PPAR
T124477	Resveratrol 4'-(6-galloylglucoside)	Resveratrol-4'-O-(6"-galloyl)glucoside	Others
	Resveratrol 4'-(6-galloylglucoside) (Resveratrol-4'-O-(6"-galloyl)glucoside) is a natural poduct found in the roots of rhubarb (Rheum palmatum L.).		Others
T4912	Jatrorrhizine chloride	Yatrorhizine chloride,Neprotine chloride	Others , 5-HT Receptor , OCT , Antibacterial , AChE
	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...		Others , 5-HT Receptor , OCT , Antibacterial , AChE
T5668	Triacetylresveratrol	Acetyl-trans-resveratrol	BCL , NF-κB , STAT
	Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.		BCL , NF-κB , STAT
T5657	Veratraldehyde	3,4-Dimethoxybenzaldehyde	Antifungal
	Veratraldehyde (3,4-Dimethoxybenzaldehyde) has antifungal activity .It is found in Cymbopogon javanensis.		Antifungal
T2804	Panaxatriol	Panaxtriol	Others
	Panaxatriol (Panaxtriol) can relieve myelosuppression induced by radiation injury.		Others
T3933	Jatrorrhizine	Yatrorizine,neprotin	MAO , 5-HT Receptor , Antibacterial , AChE
	Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...		MAO , 5-HT Receptor , Antibacterial , AChE
T2986	Jatrorrhizine hydrochloride		Others
	Jatrorrhizine hydrochloride is extracted from berberidis, radix.		Others
T5716	4'-Methoxyresveratrol	4'-O-Methylresveratrol	advanced glycation end products
	4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced...		advanced glycation end products
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
TN1413	Atranorin		Endogenous Metabolite , NO Synthase , Ras
	Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv...		Endogenous Metabolite , NO Synthase , Ras
TN1057	Veratrosine	Veratramine 3-glycoside,Veratramine-beta-D-glucoside	Platelet aggregation
	Veratrosine (Veratramine-beta-D-glucoside) is an alkaloid isolated from the herbs of Veratrum nigrum. Veratrosine exhibits feeble inhibition activity against platelet aggregation.		Platelet aggregation
T3840	Dihydroresveratrol	3,4',5-Trihydroxybibenzyl	Estrogen Receptor/ERR , Others
	Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are ...		Estrogen Receptor/ERR , Others
TN5370	1β,10β-Epoxydesacetoxymatricarin
	1beta,10beta-Epoxydesacetoxymatricarin shows high anti-hypercholesterolemic potential.
TN6045	Spegatrine
	Spegatrine is a natural product from Rauvolfia verticillata.
TN3371	Albatrelin G		Others
	Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.		Others
T13661	Docosatrienoic Acid	cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Others
	Docosatrienoic acid is a rare omega-3 fatty acid; Ki value is 5×M, which inhibits the binding of LTB4 to porcine neutrophil membrane.		Others
TMA2415	4-Prenyloxyresveratrol	4'-Prenyloxyresveratrol	Others
	4'-Prenyloxyresveratrol is a natural product from Morus wittiorum.		Others
TN2144	Resveratroloside		P450 , NO Synthase
	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.		P450 , NO Synthase
T2173	Veratridine		Sodium Channel
	Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.		Sodium Channel
T80019	17-Hydroxyneomatrine
	17-Hydroxyneomatrine, a compound derived from Sophora flavescens, exhibits multifaceted biological activities, including the inhibition of human cervical carcinoma Hela cell growth, along with broad-spectrum antibacteria...
TN1810	Jatropholone B		Others
	Jatropholone B shows antiproliferative activity against cancer cell lines. It also has gastroprotective activity in preventing the gastric lesions in mice.		Others
T73949	Isatropolone A
	Isatropolone A, a natural product with a 1,5-diketone moiety, has been reisolated from Streptomyces Gö66. This compound exhibits potent anti-Leishmania donovani activity, evidenced by an IC50 value of 0.5 μM [1].
TN5253	Wedeliatrilolactone A		Others
	Wedeliatrilolactone A is a natural product from Wedelia trilobata.		Others
TN3370	Albatrelin C		Others
	Albatrelin C is a natural product from Albatrellus ovinus.		Others
TN5666	1,4,6-Heptatrien-3-one	Bisdemethoxycurcumin,BDMC
	1,4,6-Heptatrien-3-one is a natural product for research related to life sciences. The catalog number is TN5666 and the CAS number is 52328-96-8.
TN2727	Jatrophane 2		P-gp , Antifection
	2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Ja...		P-gp , Antifection
TN6450	Quasipanaxatriol
	Quasipanaxatriol can greatly enhance the cytotoxicity of the anti-cancer drugs in P388/ADM cells.
TN3262	8(17),12E,14-Labdatrien-20-oic acid		Others
	8(17),12E,14-Labdatrien-20-oic acid is a natural product from Isodon yuennanensis.		Others
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Natural Products

Garcinone C

TN1673

Synonym:

Target: ATM/ATR, CDK, STAT, AChR, Antifection

trans-Trimethoxyresveratrol

T3330

Synonym: trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene

Target: Reactive Oxygen Species

Atractylenolide III

T3902

Synonym: ICodonolactone,8β-Hydroxyasterolide

Synonym: Atractydin

Target: Lipid

(20S)-Protopanaxatriol

T2810

Synonym: 20(S)-APPT,g-PPT

Target: Apoptosis, Estrogen Receptor/ERR, Glucocorticoid Receptor, Estrogen/progestogen Receptor, Liver X Receptor

Atraric acid

TCS1372

Synonym:

Target: Phosphatase, Androgen Receptor

Atractylenolide II

T5S0168

Synonym: 2-Atractylenolide,Asterolide

Target: Apoptosis, ERK, p38 MAPK, Akt, STAT

Veratric acid

T3744

Synonym: Veratrumenoic acid,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

Oxymatrine

T2754

Synonym: Oxysophoridine,Matrine N-oxide

Target: Influenza Virus, Autophagy, TGF-beta/Smad

Carboxyatractyloside

T8170

Synonym: Gummiferin,Carboxyatractyloside tripotassium salt

Target: Others

Matrine

T2870

Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Atractyloside potassium salt

T3S0156

Synonym: Atractyloside Dipotassium Salt

Target: Others

Veratramine

T3364

Synonym: NSC17821,NSC23880

Target: Sodium Channel

Oxyresveratrol

T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Veratryl alcohol

T0657

Synonym: 3,4-Dimethoxybenzyl alcohol

Target: IL Receptor, TNF, TLR, JAK, STAT

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14

Target: Wnt/beta-catenin

Acetylatractylodinol

TN3340

Synonym: Tractylodinol acetate

Target: Others

Protopanaxatriol

T3917

Synonym: 20(R)-APPT,20(R)-Protopanaxatriol,(20R)-Protopanaxatriol

Target: PPAR

Resveratrol 4'-(6-galloylglucoside)

T124477

Synonym: Resveratrol-4'-O-(6"-galloyl)glucoside

Target: Others

Jatrorrhizine chloride

T4912

Synonym: Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Triacetylresveratrol

T5668

Synonym: Acetyl-trans-resveratrol

Target: BCL, NF-κB, STAT

Veratraldehyde

T5657

Synonym: 3,4-Dimethoxybenzaldehyde

Synonym: Yatrorizine,neprotin

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Jatrorrhizine hydrochloride

T2986

Synonym:

Target: Others

4'-Methoxyresveratrol

T5716

Synonym: 4'-O-Methylresveratrol

Target: advanced glycation end products

Resveratrol

T1558

Synonym: trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Atranorin

TN1413

Synonym:

Target: Endogenous Metabolite, NO Synthase, Ras

Veratrosine

TN1057

Synonym: Veratramine 3-glycoside,Veratramine-beta-D-glucoside

Target: Platelet aggregation

Dihydroresveratrol

T3840

Synonym: 3,4',5-Trihydroxybibenzyl

Target: Estrogen Receptor/ERR, Others

1β,10β-Epoxydesacetoxymatricarin

Synonym: cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid

Target: Others

4-Prenyloxyresveratrol

TMA2415

Synonym: 4'-Prenyloxyresveratrol

Target: P450, NO Synthase

Veratridine

T2173

Synonym:

Target: Sodium Channel

Wedeliatrilolactone A

1,4,6-Heptatrien-3-one

TN5666

Synonym: Bisdemethoxycurcumin,BDMC

Target: P-gp, Antifection

8(17),12E,14-Labdatrien-20-oic acid

TN3262

Synonym:

Target: Others

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPJ-01333	TEM8/ANTXR1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothel...
TMPY-02286	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His)	H1N1	E. coli
	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 29.3 kDa and the accession number is B4UPA8.
TMPY-00065	Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) VP40/Matrix protein VP40 Protein (His)	EBOV	E. coli
	Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) VP40/Matrix protein VP40 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34.4 kDa and the accession number...
TMPH-01673	Human metapneumovirus (strain CAN97-83) Matrix protein (His)	HMPV	P. pastoris (Yeast)
	Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the acti...
TMPH-00451	SVSP Protein, Crotalus atrox, Recombinant (His & Myc)	Crotalus atrox	Baculovirus Insect Cells
	Snake venom serine protease that may act in the hemostasis system of the prey. SVSP Protein, Crotalus atrox, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted mol...
TMPH-00214	SVMP Protein, Bothrops atrox, Recombinant (His & Myc)	Bothrops atrox	E. coli
	SVMP Protein, Bothrops atrox, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.4 kDa and the accession number is P85420.
TMPH-02347	Influenza A H1N1 (strain A/USA:Phila/1935) Matrix protein 2 (His)	H1N1	E. coli
	Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of th...
TMPY-00064	Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Matrix protein VP40 Protein (His)	EBOV	E. coli
	Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Matrix protein VP40 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34.1 kDa and the ...
TMPH-02346	Influenza A H1N1 (strain A/USA:Iowa/1943) Matrix protein 1 (His & Myc)	H1N1	E. coli
	Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction...
TMPH-01426	HEATR6 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	HEATR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-03226	Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (GST)	RABV	E. coli
	Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates...
TMPY-00281	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His & MBP)	EBOV	E. coli
	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 79.1 kDa and the accession numb...
TMPH-00450	SVSP Protein, Crotalus atrox, Recombinant (His)	Crotalus atrox	P. pastoris (Yeast)
	SVSP Protein, Crotalus atrox, Recombinant (His) is expressed in Yeast.
TMPH-03695	VSIV (strain 98COE North America) Matrix Protein (His & Myc)	VSIV	E. coli
	VSIV (strain 98COE North America) Matrix Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.5 kDa and the accession number is Q8B0I2.
TMPY-00498	Influenza A H3N2 (A/Aichi/2/1968) Matrix protein 1/M1 Protein (His)	H3N2	E. coli
	Influenza A H3N2 (A/Aichi/2/1968) Matrix protein 1/M1 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30 kDa and the accession number is I6SGW5.
TMPY-00216	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His)	EBOV	E. coli
	Ebola virus EBOV (subtype Sudan, strain Gulu) VP40/Matrix protein VP40 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34.5 kDa and the accession number is B0LPL6.
TMPH-02348	Influenza A H1N1 (strain A/Puerto Rico/8/1934) Matrix protein 2 (His & Myc)	H1N1	E. coli
	Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of th...
TMPH-01643	Matrilin-3/MATN3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
TMPH-03227	Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (His)	RABV	E. coli
	Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.7 kDa and the accession number is P15197.
TMPH-03225	Rabies virus (RABV) (strain CVS-11) Matrix Protein (His & Myc)	RABV	E. coli
	Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates...
TMPH-03692	VSIV (strain San Juan) Matrix Protein (His & Myc)	VSIV	E. coli
	VSIV (strain San Juan) Matrix Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.5 kDa and the accession number is P03519.
TMPH-00213	Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc)	Bothrops atrox	E. coli
	Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor a...
TMPY-00284	Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP40/Matrix protein VP40 Protein (His & MBP)	EBOV	E. coli
	Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP40/Matrix protein VP40 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight i...
TMPH-03228	Rabies virus (RABV) (strain SAD B19) Matrix Protein (His)	RABV	E. coli
	Rabies virus (RABV) (strain SAD B19) Matrix Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.7 kDa and the accession number is P16285.
TMPH-01672	Human metapneumovirus (strain CAN97-83) Matrix protein (His & Myc)	HMPV	E. coli
	Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the acti...
TMPH-00449	Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc)	Crotalus atrox	Baculovirus Insect Cells
	Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc) is expressed in Baculovirus.
TMPH-03694	VSIV (strain Glasgow) Matrix Protein (His & Myc)	VSIV	Baculovirus Insect Cells
	VSIV (strain Glasgow) Matrix Protein (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 30.7 kDa and the accession number is P04876.
TMPY-00496	Influenza A H1N1 (A/Brevig Mission/1/1918) Matrix protein 1/M1 Protein (His)	H1N1	E. coli
	Influenza A H1N1 (A/Brevig Mission/1/1918) Matrix protein 1/M1 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30 kDa and the accession number is Q8BAC3.1.
TMPH-03036	Cytotoxin 2 Protein, Naja atra, Recombinant (His & Myc)	Naja atra	E. coli
	Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a modera...
TMPH-02382	Lake Victoria marburgvirus (MARV) (strain Angola/2005) Matrix protein VP40 (His & SUMO)	MARV	E. coli
	Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. The interaction with host E3 ubiquitin ligase SMURF2 ...
TMPH-03693	VSIV (strain Glasgow) Matrix Protein (His)	VSIV	E. coli
	VSIV (strain Glasgow) Matrix Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P04876.
TMPY-03844	Influenza A H7N9 (A/Anhui/1/2013) Matrix protein 1/M1 Protein (His)	H7N9	E. coli
	Influenza A H7N9 (A/Anhui/1/2013) Matrix protein 1/M1 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 28.5 kDa.
TMPY-03976	EEF1E1 Protein, Human, Recombinant (His)	Human	E. coli
	EEF1E1, also known as AIMP3 and p18, is a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, EEF1E1 is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex...
TMPJ-00870	NCK1 Protein, Human, Recombinant (His)	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, ...
TMPY-02228	P53 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...