store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 165.00 | |
10 mg | In stock | $ 257.00 | |
25 mg | In stock | $ 496.00 | |
50 mg | In stock | $ 692.00 | |
100 mg | In stock | $ 979.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 187.00 |
Description | Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells. |
Synonyms | M1774, ATR inhibitor 1 |
Molecular Weight | 370.32 |
Formula | C16H12F2N8O |
CAS No. | 1613200-51-3 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tuvusertib 1613200-51-3 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Others PI3K/Akt/mTOR signaling Chk ATM/ATR M1774 M 1774 ATR inhibitor 1 M-1774 inhibitor inhibit