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Jatrorrhizine chloride

Catalog No. T4912 CAS 6681-15-8

Synonyms: Yatrorhizine chloride, Neprotine chloride

Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced Apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

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Jatrorrhizine chloride, CAS 6681-15-8

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Purity: 98%

Biological Description

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Description	Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Targets&IC50	AChE:872 nM (IC50)
In vitro	Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT.

Synonyms	Yatrorhizine chloride, Neprotine chloride
Molecular Weight	373.8
Formula	C20H20ClNO4
CAS No.	6681-15-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mg/mL (13.38 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

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Keywords

Jatrorrhizine chloride 6681-15-8 GPCR/G Protein Membrane transporter/Ion channel Microbiology/Virology Neuroscience Others 5-HT Receptor OCT Antibacterial AChE Jatrorrhizine Bacterial antiamoebic depressive disorder neuroprotective Yatrorhizine chloride antimicrobial Cytotoxic alkaloid Serotonin Receptor antioxidant Neprotine chloride Inhibitor inhibit antiplasmodial antidepressant quaternary isoquinoline antidepressant-like Alzheimer’s disease Cholinesterase (ChE) 5-hydroxytryptamine Receptor E. histolytica falciparum inhibitor

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