Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Description | Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons. |
Targets&IC50 | AChE:872 nM (IC50) |
In vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT. |
Synonyms | Yatrorhizine chloride, Neprotine chloride, 盐酸药根碱 |
Molecular Weight | 373.8 |
Formula | C20H20ClNO4 |
CAS No. | 6681-15-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 5 mg/mL (13.38 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Jatrorrhizine chloride 6681-15-8 G蛋白偶联受体 离子通道 其他 神经科学 微生物学 5-HT Receptor AChE Antibacterial OCT Others Jatrorrhizine Bacterial antiamoebic depressive disorder neuroprotective Yatrorhizine chloride antimicrobial Cytotoxic alkaloid Serotonin Receptor antioxidant Neprotine chloride Inhibitor inhibit antiplasmodial antidepressant quaternary isoquinoline antidepressant-like Alzheimer’s disease Cholinesterase (ChE) 5-hydroxytryptamine Receptor E. histolytica falciparum inhibitor