Shopping Cart
- Remove All
Your shopping cart is currently empty
Jatrorrhizine chloride
🥰Excellent
Catalog No. T4912Cas No. 6681-15-8
Alias Yatrorhizine chloride, Neprotine chloride
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Jatrorrhizine chloride
🥰Excellent
Purity: 99.79%
Catalog No. T4912Alias Yatrorhizine chloride, Neprotine chlorideCas No. 6681-15-8
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $51 | In Stock | |
| 25 mg | $92 | In Stock | |
| 50 mg | $157 | In Stock | |
| 100 mg | $233 | In Stock | |
| 500 mg | $553 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $35 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:99.79%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons. |
| Targets&IC50 | AChE:872 nM (IC50) |
| In vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT. |
| Synonyms | Yatrorhizine chloride, Neprotine chloride |
| Molecular Weight | 373.8 |
| Formula | C20H20ClNO4 |
| Cas No. | 6681-15-8 |
| Smiles | [Cl-].COc1cc-2c(CC[n+]3cc4c(OC)c(OC)ccc4cc-23)cc1O |
| Relative Density. | no data available |
| Color | Orange |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (21.4 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Yatrorhizine ChlorideSerotonin Receptorquaternary isoquinolinePMATOCTneuroprotectiveNeprotine ChlorideJatrorrhizine chlorideJatrorrhizine ChlorideJatrorrhizineInhibitorinhibitfalciparumE. histolyticadepressive disorderCytotoxicCholinesterase (ChE)Bacterialantiplasmodialantioxidantantimicrobialantidepressant-likeantidepressantantiamoebicAlzheimer's diseasealkaloidAChE5-hydroxytryptamine Receptor5HTReceptor5-HT Receptor5HT Receptor
Preview
Related Tags: buy Jatrorrhizine chloride | purchase Jatrorrhizine chloride | Jatrorrhizine chloride cost | order Jatrorrhizine chloride | Jatrorrhizine chloride chemical structure | Jatrorrhizine chloride in vitro | Jatrorrhizine chloride formula | Jatrorrhizine chloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.