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Jatrorrhizine chloride
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Purity:99.79%
Jatrorrhizine chloride
Catalog No. T4912Cas No. 6681-15-8
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $51 | In Stock | |
| 25 mg | $92 | In Stock | |
| 50 mg | $157 | In Stock | |
| 100 mg | $233 | In Stock | |
| 500 mg | $553 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $35 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons. |
| In vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT. |
| Alias | Yatrorhizine chloride, Neprotine chloride |
| Molecular Weight | 373.8 |
| Formula | C20H20ClNO4 |
| Cas No. | 6681-15-8 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (21.4 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Keywords
JatrorrhizineBacterialantiamoebicdepressive disorderneuroprotectiveJatrorrhizine chlorideJatrorrhizine ChlorideantimicrobialCytotoxic5-HT ReceptoralkaloidSerotonin ReceptorantioxidantInhibitorinhibitYatrorhizine ChlorideNeprotine Chlorideantiplasmodialantidepressantquaternary isoquinolineantidepressant-likeAlzheimer’s diseaseCholinesterase (ChE)5-hydroxytryptamine ReceptorE. histolyticafalciparum
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