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Jatrorrhizine chloride

Catalog No. T4912   CAS 6681-15-8
Synonyms: Yatrorhizine chloride, Neprotine chloride

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

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Jatrorrhizine chloride Chemical Structure
Jatrorrhizine chloride, CAS 6681-15-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 64.00
25 mg In stock $ 115.00
50 mg In stock $ 178.00
100 mg In stock $ 268.00
500 mg In stock $ 553.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 99.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Targets&IC50 AChE:872 nM (IC50)
In vitro Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT.
Source
Synonyms Yatrorhizine chloride, Neprotine chloride
Molecular Weight 373.8
Formula C20H20ClNO4
CAS No. 6681-15-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (13.38 mM)

TargetMolReferences and Literature

1. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Parasitic Compound Library Anti-infective Natural Product Library GPCR Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Inhibitor Library Traditional Chinese Medicine Monomer Library Anti-Cancer Compound Library Natural Product Library for HTS

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Keywords

Jatrorrhizine chloride 6681-15-8 GPCR/G Protein Membrane transporter/Ion channel Microbiology/Virology Neuroscience Others 5-HT Receptor OCT Antibacterial AChE Jatrorrhizine Bacterial antiamoebic depressive disorder neuroprotective Jatrorrhizine Chloride antimicrobial Cytotoxic alkaloid Serotonin Receptor antioxidant Inhibitor inhibit Yatrorhizine Chloride Neprotine Chloride antiplasmodial antidepressant quaternary isoquinoline antidepressant-like Alzheimer’s disease Cholinesterase (ChE) 5-hydroxytryptamine Receptor E. histolytica Yatrorhizine chloride falciparum Neprotine chloride inhibitor

 

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