Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 115.00 | |
50 mg | In stock | $ 178.00 | |
100 mg | In stock | $ 268.00 | |
500 mg | In stock | $ 553.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons. |
Targets&IC50 | AChE:872 nM (IC50) |
In vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT. |
Source |
Synonyms | Yatrorhizine chloride, Neprotine chloride |
Molecular Weight | 373.8 |
Formula | C20H20ClNO4 |
CAS No. | 6681-15-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (13.38 mM)
You can also refer to dose conversion for different animals. More
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Jatrorrhizine chloride 6681-15-8 GPCR/G Protein Membrane transporter/Ion channel Microbiology/Virology Neuroscience Others 5-HT Receptor OCT Antibacterial AChE Jatrorrhizine Bacterial antiamoebic depressive disorder neuroprotective Jatrorrhizine Chloride antimicrobial Cytotoxic alkaloid Serotonin Receptor antioxidant Inhibitor inhibit Yatrorhizine Chloride Neprotine Chloride antiplasmodial antidepressant quaternary isoquinoline antidepressant-like Alzheimer’s disease Cholinesterase (ChE) 5-hydroxytryptamine Receptor E. histolytica Yatrorhizine chloride falciparum Neprotine chloride inhibitor