Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 87.00 | |
5 mg | In stock | $ 213.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 463.00 | |
50 mg | In stock | $ 592.00 | |
100 mg | In stock | $ 787.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 235.00 |
Description | Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
Targets&IC50 | ACAT-1:EC50 of 9 nM |
In vitro | In H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity.?Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[2]. |
Synonyms | PD-132301 hydrochloride, ATR101 hydrochloride |
Molecular Weight | 458.08 |
Formula | C27H40ClN3O |
CAS No. | 133825-81-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41.67 mg/mL (90.97 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Nevanimibe hydrochloride 133825-81-7 Apoptosis Metabolism Acyltransferase cancer O-acyltransferase ATR-101 Hydrochloride acyl-CoA:cholesterol acyltransferase PD 132301 Hydrochloride acyl-coenzyme PD-132301 Diglyceride acyltransferase orally adrenocortical A:cholesterol mono- acylglycerol acyltransferase inhibit ATR101 Hydrochloride PD132301 Hydrochloride ATR 101 Hydrochloride PD 132301 PD-132301 Hydrochloride Nevanimibe Hydrochloride Nevanimibe ATR 101 PD132301 ATR-101 Diacylglycerol acyltransferase active ATR101 Inhibitor PD-132301 hydrochloride ATR101 hydrochloride inhibitor