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Nevanimibe hydrochloride

Catalog No. T12225L   CAS 133825-81-7
Synonyms: PD-132301 hydrochloride, ATR101 hydrochloride

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).

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Nevanimibe hydrochloride Chemical Structure
Nevanimibe hydrochloride, CAS 133825-81-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 87.00
5 mg In stock $ 213.00
10 mg In stock $ 297.00
25 mg In stock $ 463.00
50 mg In stock $ 592.00
100 mg In stock $ 787.00
1 mL * 10 mM (in DMSO) In stock $ 235.00
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Purity: 99.25%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
Targets&IC50 ACAT-1:EC50 of 9 nM
In vitro In H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity.?Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[2].
Synonyms PD-132301 hydrochloride, ATR101 hydrochloride
Molecular Weight 458.08
Formula C27H40ClN3O
CAS No. 133825-81-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41.67 mg/mL (90.97 mM), sonification is recommended.

TargetMolReferences and Literature

1. LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157(5):1775-88.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library Clinical Compound Library Apoptosis Compound Library Metabolism Compound Library NO PAINS Compound Library Lipid Metabolism Compound Library

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Keywords

Nevanimibe hydrochloride 133825-81-7 Apoptosis Metabolism Acyltransferase cancer O-acyltransferase ATR-101 Hydrochloride acyl-CoA:cholesterol acyltransferase PD 132301 Hydrochloride acyl-coenzyme PD-132301 Diglyceride acyltransferase orally adrenocortical A:cholesterol mono- acylglycerol acyltransferase inhibit ATR101 Hydrochloride PD132301 Hydrochloride ATR 101 Hydrochloride PD 132301 PD-132301 Hydrochloride Nevanimibe Hydrochloride Nevanimibe ATR 101 PD132301 ATR-101 Diacylglycerol acyltransferase active ATR101 Inhibitor PD-132301 hydrochloride ATR101 hydrochloride inhibitor

 

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