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Satraplatin

Catalog No. T7221   CAS 129580-63-8
Synonyms: BMS182751, JM216, BMY45594

Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.

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Satraplatin Chemical Structure
Satraplatin, CAS 129580-63-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 100.00
5 mg In stock $ 247.00
10 mg In stock $ 396.00
25 mg In stock $ 648.00
50 mg In stock $ 892.00
100 mg In stock $ 1,230.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
In vitro KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].
Cell Research CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].
Synonyms BMS182751, JM216, BMY45594
Molecular Weight 500.28
Formula C10H22Cl2N2O4Pt
CAS No. 129580-63-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (65.96 mM), DMSO inactivates the activity of Satraplatin.

TargetMolReferences and Literature

1. Yamano Y , Shiiba M , Negoro K , et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells[J]. Head & Neck, 2010, 33(3):309-317. 2. Bhargava A , Vaishampayan U N . Satraplatin: leading the new generation of oral platinum agents[J]. Expert Opinion on Investigational Drugs, 2009, 18(11):1787-1797.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Anti-Lung Cancer Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max

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Keywords

Satraplatin 129580-63-8 DNA Damage/DNA Repair DNA Alkylation DNA Alkylator/Crosslinker BMS 182751 BMY-45594 BMS182751 JM216 BMS-182751 BMY 45594 JM 216 Inhibitor inhibit BMY45594 JM-216 inhibitor

 

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