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Satraplatin

Catalog No. T7221 CAS 129580-63-8

Synonyms: BMS182751, 沙铂, JM216, 顺式-二氯-反式-二乙酸-氨-环己胺合铂, BMY45594

Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.

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Satraplatin, CAS 129580-63-8

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Purity: 98%

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Storage & Solubility Information

Description	Satraplatin is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
In vitro	KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].
Cell Research	CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].

Synonyms	BMS182751, 沙铂, JM216, 顺式-二氯-反式-二乙酸-氨-环己胺合铂, BMY45594
Molecular Weight	498.26
Formula	C10H20Cl2N2O4Pt
CAS No.	129580-63-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 33 mg/mL (65.96 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yamano Y , Shiiba M , Negoro K , et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells[J]. Head & Neck, 2010, 33(3):309-317. 2. Bhargava A , Vaishampayan U N . Satraplatin: leading the new generation of oral platinum agents[J]. Expert Opinion on Investigational Drugs, 2009, 18(11):1787-1797.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library DNA Damage & Repair Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Aging Compound Library Bioactive Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Methyl methanesulfonate O6-Benzylguanine Satraplatin Palifosfamide Miriplatin hydrate Duocarmycin Analog VAL-083 Lobaplatin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Satraplatin 129580-63-8 DNA损伤和修复 DNA Alkylation DNA Alkylator/Crosslinker BMY 45594 JM216 BMS-182751 BMY-45594 BMS182751 JM 216 inhibit Inhibitor BMS 182751 BMY45594 JM-216 inhibitor

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