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Resveratrol

Catalog No. T1558   CAS 501-36-0
Synonyms: trans-Resveratrol, SRT 501

Resveratrol (trans-Resveratrol) is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Resveratrol Chemical Structure
Resveratrol, CAS 501-36-0
Pack Size Availability Price/USD Quantity
100 mg In stock $ 36.00
200 mg In stock $ 50.00
500 mg In stock $ 76.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.9%
Purity: 99.82%
Purity: 99.53%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Resveratrol (trans-Resveratrol) is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Targets&IC50 COX1:1.1 μM (cell free), COX-2:1.3 μM (cell free), DNA polymerases α:3.3 μM (cell free), DNA polymerases δ:5 μM (cell free)
In vitro Resveratrol inhibits cellular events associated with tumor initiation, promotion, and progression. Resveratrol inhibited the hydroperoxidase activity of COX-1 (ED50 = 3.7 μM) [1]. Resveratrol inhibits the activity of COX-1 and COX-2 (IC50s: 1.1 μM and 1.3 μM for COX-1 and COX-2, respectively) [2]. Resveratrol inhibited TPA-induced DNA binding of NF-kB. Moreover, resveratrol reduced the levels of p65/RelA, a functionally active subunit of NF-kB in nuclear fractions prepared from TPA-treated mouse skin. Resveratrol pretreatment significantly inhibited the phosphorylation of p65-(Ser-536) induced by TPA. Resveratrol pretreatment significantly attenuated TPA-induced stimulation of IKKa and IKKb activity [3]. DNA polymerase inhibiting activity of resveratrol was found to occur at 10 μM in an SV40 viral DNA replication assay. Resveratrol inhibits DNA polymerases α and δ (IC50s: 3.3 and 5 μM, respectively) [4].
In vivo Resveratrol (RSV) treatment significantly upregulated eNOS gene expression and the levels of phosphorylated CREB in the aorta compared with the untreated control mice. Simultaneously, RSV treatment was observed to upregulate PKA activity and cGMP levels and inhibited superoxide generation in the aorta compared with untreated mice. Compared to vehicle-treated mice, chronic RSV treatment resulted in a significant improvement in endothelium-dependent vasorelaxation response to Ach. Treatment with RSV markedly attenuated the area of atherosclerotic lesions [5].
Cell Research HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was stopped by adding ice-cold 6% trichloroacetic acid and the supernatant fractions of the cellular lysates were extracted, dried and acetylated. Cyclic GMP levels were determined by an enzyme immunoassay kit and results standardized by protein levels [5].
Animal Research Eight-week male apoE-/- mice (C57BL/6 background) were used in the study. Mice were housed in photobiologic light-exposure chambers with a 12:12-h light:dark cycle, and eat food ad libitum. Mice were randomly divided into two groups: one group receiving a high cholesterol diet (HCD, 21% fat, 19.5% casein, and 1.5% cholesterol), the other receiving HCD supplemented with RSV (200 mg/100 g diet). All mice were fed for 8 weeks. To identify the potential role of PKA, some mice were treated with PKA specific inhibitor (KT5720, 1.2 mg/kg) via intraperitoneal injection once a day at the last 4 weeks. The animal experiments were conducted according to the institutional guidelines of Guangdong Provincial People's Hospital [5].
Source
Synonyms trans-Resveratrol, SRT 501
Molecular Weight 228.24
Formula C14H12O3
CAS No. 501-36-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42 mg/mL (184 mM)

H2O: <1 mg/mL

Ethanol: <1 mg/mL

TargetMolReferences and Literature

1. Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218-20. 2. Calamini B, et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J. 2010 Jul 15;429(2):273-82. 3. Kundu JK, et al. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis. 2006 Jul;27(7):1465-74. 4. Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32. 5. Li J, et al. Resveratrol improves endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice. J Nutr Biochem. 2019 Feb 10;67:63-71. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Pang K, Li B, Tang Z, et al. Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis[J]. Molecular medicine reports. 2020, 22(4): 3440-3452. 8. Zhang K, Pan X, Zheng J, et al. SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation[J]. Molecular Biology Reports. 2020, 47(3): 2149-2159. 9. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 10. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.

TargetMolCitations

1. Cai Z, Wu X, Song Z, et al.Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis.Cell Discovery.2023, 9(1): 104. 2. Huang L, Wang J, Ma X, et al.Inhibition of influenza A virus infection by natural stilbene piceatannol targeting virus hemagglutinin.Phytomedicine.2023: 155058. 3. Chen S, Chen W, Li Z, et al.Regulation of PM2. 5 on mitochondrial damage in H9c2 cells through miR-421/SIRT3 pathway and protective effect of miR-421 inhibitor and resveratrol.Journal of Environmental Sciences.2023 4. Chu Z, Li W, You G, et al.Resveratrol, a New Allosteric Effector of Hemoglobin, Enhances Oxygen Supply Efficiency and Improves Adaption to Acute Severe Hypoxia.Molecules.2023, 28(5): 2050. 5. Wang W, Zeng Z, Zhang J, et al.A Systematic Study of Traditional Chinese Medicine for the Treatment of Lung Adenocarcinoma Using a Reverse Network of Key Targets Based on Bioinformatics and Molecular Docking: Curcumin and Trans-Resveratrol as Potential Drug Candidates for Lung Adenocarcinoma.Natural Product Communications.2023, 18(5): 1934578X231169370. 6. Zareifi D S, Chaliotis O, Chala N, et al. A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease. Iscience. 2022, 25(3): 103890 7. Zhang K, Pan X, Zheng J, et al. SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation. Molecular Biology Reports. 2020, 47(3): 2149-2159 8. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 9. Su M, Zhao W, Li Y, et al. Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. Nutrients. 2022, 14(21): 4518. 10. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1.
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Keywords

Resveratrol 501-36-0 Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation Metabolism Microbiology/Virology Neuroscience NF-Κb Mitophagy IκB/IKK Lipoxygenase Sirtuin COX NADPH DNA/RNA Synthesis Nrf2 Antibacterial Antibiotic Antifungal Bacterial Fungal Inhibitor SRT-501 inhibit Mitochondrial Autophagy IKK I kappa B kinase trans-Resveratrol Keap1-Nrf2 IκB kinase SRT 501 SRT501 inhibitor

 

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