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NF-Κb IκB/IKK Resveratrol

Resveratrol

Catalog No. T1558   CAS 501-36-0
Synonyms: trans-Resveratrol, SRT 501

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.

Resveratrol, CAS 501-36-0
Pack Size Availability Price/USD Quantity
50 mg In stock 30.00
100 mg In stock 42.00
200 mg In stock 50.00
500 mg In stock 85.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
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Description Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Targets&IC50 COX-1 : IC50:1.1μM,   COX-2 : ic50 1.3 μM (cell free),   DNA polymerase α : ic50 3.3μM,   IKKβ : ic50 1μM,   LOX : IC50:3.7μM,   Quinone reductase 2 : ic50 35nM-50nM,   SIRT1,   SIRT2,   COX1 : ic50 1.1 μM (cell free),   DNA polymerases α : ic50 3.3 μM (cell free),   DNA polymerases δ : ic50 5 μM (cell free),  
In vivo Resveratrol (RSV) treatment significantly upregulated eNOS gene expression and the levels of phosphorylated CREB in the aorta compared with the untreated control mice. Simultaneously, RSV treatment was observed to upregulate PKA activity and cGMP levels and inhibited superoxide generation in the aorta compared with untreated mice. Compared to vehicle-treated mice, chronic RSV treatment resulted in a significant improvement in endothelium-dependent vasorelaxation response to Ach. Treatment with RSV markedly attenuated the area of atherosclerotic lesions [5].
Cell Research
HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was stopped by adding ice-cold 6% trichloroacetic acid and the supernatant fractions of the cellular lysates were extracted, dried and acetylated. Cyclic GMP levels were determined by an enzyme immunoassay kit and results standardized by protein levels [5].
Cell lines: Human breast cancer cell MCF-7
Animal Research
Eight-week male apoE-/- mice (C57BL/6 background) were used in the study. Mice were housed in photobiologic light-exposure chambers with a 12:12-h light:dark cycle, and eat food ad libitum. Mice were randomly divided into two groups: one group receiving a high cholesterol diet (HCD, 21% fat, 19.5% casein, and 1.5% cholesterol), the other receiving HCD supplemented with RSV (200 mg/100 g diet). All mice were fed for 8 weeks. To identify the potential role of PKA, some mice were treated with PKA specific inhibitor (KT5720, 1.2 mg/kg) via intraperitoneal injection once a day at the last 4 weeks. The animal experiments were conducted according to the institutional guidelines of Guangdong Provincial People’s Hospital [5].
Animal Model: Human ovarian xenografts PA-1
Synonyms trans-Resveratrol , SRT 501
Purity 99.90%
Molecular Weight 228.24
Formula C14H12O3
CAS No. 501-36-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 42 mg/mL (184 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

0.5% CMC Na: 30 mg/mL

Citations

References and Literature
1. Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218-20. 2. Calamini B, et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J. 2010 Jul 15;429(2):273-82. 3. Kundu JK, et al. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis. 2006 Jul;27(7):1465-74. 4. Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32. 5. Li J, et al. Resveratrol improves endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice. J Nutr Biochem. 2019 Feb 10;67:63-71.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Anti-diabetic Compound Library Stem cell Differentiation Compound Library Anti-infection Compound Library Autophagy Compound Library Neuronal Signaling Compound Library Epigenetics Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library DNA Damage & Repair Compound Library Kinase Inhibitor Library Bioactive Lipid Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Histone Modification Research Compound Library NF-κB Signaling Compound Library

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