Cart
NF-Κb IκB/IKK Resveratrol

Resveratrol

Catalog No. T1558   CAS 501-36-0
Synonyms: trans-Resveratrol, SRT 501

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.

Resveratrol, CAS 501-36-0
Pack Size Availability Price/USD Quantity
50 mg In stock 30.00
100 mg In stock 42.00
200 mg In stock 50.00
500 mg In stock 85.00
1 mL * 10 mM (in DMSO) In stock 50.00
Bulk Inquiry
Get quote
Select Batch  
Purity 99.90%
Purity 99.82%
Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Targets&IC50 COX-1 ,   COX-2 ,   DNA polymerase α ,   IKKβ ,   LOX ,   Quinone reductase 2 ,   SIRT1 ,   SIRT2 ,   COX1 ,   DNA polymerases α ,   DNA polymerases δ
In vivo Resveratrol (RSV) treatment significantly upregulated eNOS gene expression and the levels of phosphorylated CREB in the aorta compared with the untreated control mice. Simultaneously, RSV treatment was observed to upregulate PKA activity and cGMP levels and inhibited superoxide generation in the aorta compared with untreated mice. Compared to vehicle-treated mice, chronic RSV treatment resulted in a significant improvement in endothelium-dependent vasorelaxation response to Ach. Treatment with RSV markedly attenuated the area of atherosclerotic lesions [5].
Cell Research
HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was stopped by adding ice-cold 6% trichloroacetic acid and the supernatant fractions of the cellular lysates were extracted, dried and acetylated. Cyclic GMP levels were determined by an enzyme immunoassay kit and results standardized by protein levels [5].
Cell lines: Human breast cancer cell MCF-7
Animal Research
Eight-week male apoE-/- mice (C57BL/6 background) were used in the study. Mice were housed in photobiologic light-exposure chambers with a 12:12-h light:dark cycle, and eat food ad libitum. Mice were randomly divided into two groups: one group receiving a high cholesterol diet (HCD, 21% fat, 19.5% casein, and 1.5% cholesterol), the other receiving HCD supplemented with RSV (200 mg/100 g diet). All mice were fed for 8 weeks. To identify the potential role of PKA, some mice were treated with PKA specific inhibitor (KT5720, 1.2 mg/kg) via intraperitoneal injection once a day at the last 4 weeks. The animal experiments were conducted according to the institutional guidelines of Guangdong Provincial People’s Hospital [5].
Synonyms trans-Resveratrol , SRT 501
Purity 99.90%
Molecular Weight 228.24
Formula C14H12O3
CAS No. 501-36-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 42 mg/mL (184 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

0.5% CMC Na: 30 mg/mL

Citations

References and Literature
1. Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218-20. 2. Calamini B, et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J. 2010 Jul 15;429(2):273-82. 3. Kundu JK, et al. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis. 2006 Jul;27(7):1465-74. 4. Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32. 5. Li J, et al. Resveratrol improves endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice. J Nutr Biochem. 2019 Feb 10;67:63-71. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Pang K, Li B, Tang Z, et al. Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis[J]. Molecular medicine reports. 2020, 22(4): 3440-3452. 8. Zhang K, Pan X, Zheng J, et al. SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation[J]. Molecular Biology Reports. 2020, 47(3): 2149-2159. 9. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 10. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Anti-diabetic Compound Library Stem cell Differentiation Compound Library Anti-infection Compound Library Apoptosis Compound Library Autophagy Compound Library Neuronal Signaling Compound Library Epigenetics Compound Library Human Endogenous Metabolite Compound Library Oxidation-Reduction Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library DNA Damage & Repair Compound Library Kinase Inhibitor Library Bioactive Lipid Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Polyphenolic Natural Compound Library Killers Collection Anti-cancer Metabolism Compound Library Histone Modification Research Compound Library NF-κB Signaling Compound Library Anti-obesity Compound Library Anti-aging Compound Library Chromatin Modification Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Active Compound library Anti-cancer Drug library Drug Repurposing Library Target-Focused Phenotypic Screening Library HIF-1 Signaling Pathway Compound Library Ferroptosis Compound Library Neurodegenerative disease-related Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Drug-induced Liver Injury (DILI) Compound Library Nonsteroidal Antiinflammatory Compound Library FDA Approved & Pharmacopeial Drug Library Lipid Metabolism Compound Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library Endoplasmic Reticulum Stress Compound Library Glutamine Metabolism Compound Library Anti-fibrosis Compound Library

Related Products

Related compounds with same targets
Cambinol Pamicogrel HALOFUGINONE LACTATE Ketorolac Polmacoxib 2,4-Dichlorophenoxyacetic acid NNK SRT1460

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.