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Matrine

Name: Matrine
Brand: TargetMol
SKU: T2870
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2870Cas No. 519-02-8

Alias α-Matrine, Vegard, Matrinium, (+)-Matrine

Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

Matrine

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Purity: 97.16%

Catalog No. T2870Alias α-Matrine, Vegard, Matrinium, (+)-MatrineCas No. 519-02-8

Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

Pack Size	Price	Availability
25 mg	$36	In Stock
50 mg	$53	In Stock
100 mg	$74	In Stock
200 mg	$119	In Stock
500 mg	$263	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:97.16%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
In vitro	In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio.
In vivo	In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg.
Synonyms	α-Matrine, Vegard, Matrinium, (+)-Matrine

Chemical Properties

Molecular Weight	248.36
Formula	C₁₅H₂₄N₂O
Cas No.	519-02-8
Smiles	O=C1CCCC2C3CCCN4CCCC(CN12)C34
Relative Density.	1.16 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 49 mg/mL (197.29 mM), Sonication is recommended.

H2O: 11 mg/mL (44.29 mM), Heating is recommended.

DMSO: 45 mg/mL (181.19 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.0264 mL	20.1321 mL	40.2641 mL	201.3207 mL
5 mM	0.8053 mL	4.0264 mL	8.0528 mL	40.2641 mL
10 mM	0.4026 mL	2.0132 mL	4.0264 mL	20.1321 mL
20 mM	0.2013 mL	1.0066 mL	2.0132 mL	10.0660 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0805 mL	0.4026 mL	0.8053 mL	4.0264 mL
100 mM	0.0403 mL	0.2013 mL	0.4026 mL	2.0132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc