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Jatrorrhizine

Catalog No. T3933 CAS 3621-38-3

Synonyms: Yatrorizine, neprotin

Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).

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Jatrorrhizine, CAS 3621-38-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 136.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 298.00

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Purity: 99.06%

Purity: 98.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
Targets&IC50	MAO-A:4 μm, MAO-B:62μm
Source	Natural Products > Rutaceae > Phellodendron

Synonyms	Yatrorizine, neprotin
Molecular Weight	338.38
Formula	C20H20NO4
CAS No.	3621-38-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 61 mg/mL(180.3 mM)

References and Literature

1. Wu H1, He K2, Wang Y2, et al.The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis.Phytomedicine. 2014 Sep 25;21(11):1373-81. 2. Li J1, Li J, Jiao Y, Dong C.Spectroscopic analysis and molecular modeling on the interaction of jatrorrhizine with human serum albumin (HSA).Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:48-54. 3. Mi R1, Hu YJ, Fan XY, Ouyang Y, Bai AM.Exploring the site-selective binding of jatrorrhizine to human serum albumin: spectroscopic and molecular modeling approaches.Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 3;117:163-9.

Citations

1. Kim Y J, Kim T I, Lee A, et al.Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice.Pharmaceuticals.2023, 17(1): 6.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Inhibitor Library GPCR Compound Library Traditional Chinese Medicine Monomer Library Anti-Parasitic Compound Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Orally Active Compound Library NO PAINS Compound Library RO5 Drug-like Natural Product Library

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MAO-B-IN-17 Cassiaside B2 Toloxatone 1,4-Naphthoquinone Salvigenin RN-1 dihydrochloride Tetrahydroharmine 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate

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Keywords

Jatrorrhizine 3621-38-3 GPCR/G Protein Metabolism Microbiology/Virology Neuroscience AChE Antibacterial 5-HT Receptor MAO depressive disorder Cholinesterase (ChE) antiamoebic Cytotoxic inhibit antimicrobial antiplasmodial quaternary isoquinoline antidepressant-like Bacterial Serotonin Receptor Yatrorizine neuroprotective antioxidant alkaloid 5-hydroxytryptamine Receptor Alzheimer’s disease E. histolytica antidepressant falciparum Inhibitor neprotin inhibitor

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