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Jatrorrhizine

Catalog No. T3933 CAS 3621-38-3

Synonyms: neprotin, Yatrorizine

Jatrorrhizine is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).

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Jatrorrhizine, CAS 3621-38-3

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Jatrorrhizine is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
Targets&IC50	MAO-B:62μm, MAO-A:4 μm

Synonyms	neprotin, Yatrorizine
Molecular Weight	338.38
Formula	C20H20NO4
CAS No.	3621-38-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 61 mg/mL(180.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wu H1, He K2, Wang Y2, et al.The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis.Phytomedicine. 2014 Sep 25;21(11):1373-81. 2. Li J1, Li J, Jiao Y, Dong C.Spectroscopic analysis and molecular modeling on the interaction of jatrorrhizine with human serum albumin (HSA).Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:48-54. 3. Mi R1, Hu YJ, Fan XY, Ouyang Y, Bai AM.Exploring the site-selective binding of jatrorrhizine to human serum albumin: spectroscopic and molecular modeling approaches.Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 3;117:163-9.

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Keywords

Jatrorrhizine 3621-38-3 GPCR/G Protein Metabolism Microbiology/Virology Neuroscience AChE MAO 5-HT Receptor Antibacterial depressive disorder Cholinesterase (ChE) antiamoebic Cytotoxic inhibit antimicrobial antiplasmodial quaternary isoquinoline antidepressant-like Bacterial Serotonin Receptor neprotin neuroprotective antioxidant alkaloid 5-hydroxytryptamine Receptor Alzheimer’s disease E. histolytica antidepressant falciparum Inhibitor Yatrorizine inhibitor

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