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Search Result

Search Results for " tgf-beta "

Targets

TGF-beta/Smad TGF-beta/Smad

49

Compounds

11

Natural Products

177

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T4283 SRI-011381 TGF-beta/Smad
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T16708 R-268712 ALK , TGF-beta/Smad
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.
T1748 Kartogenin KGN TGF-beta/Smad
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T3636 (E)-SIS3 SIS3,SIS3 HCl TGF-beta/Smad
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...
T5197 BIBF0775 ALK , TGF-beta/Smad
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
T2123 LY2109761 Autophagy , TGF-beta/Smad
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
T4662 SJ000291942 TGF-beta/Smad
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
T1800 GW788388 GW 788388 ALK , TGF-beta/Smad
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T2462 SB-505124 ALK , TGF-beta/Smad
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T4975 SM 16 ALK , TGF-beta/Smad
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T1763 SB 525334 SB525334 ALK , TGF-beta/Smad
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T1942 DMH-1 DMH1 ALK , Autophagy , TGF-beta/Smad
DMH-1 is a potent and selective BMP inhibitor.
T1914 K02288 K 02288 ALK , TGF-beta/Smad
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T1449 Hydrochlorothiazide HCTZ Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T5129 SRI-011381 hydrochloride SRI-011381 hydrochloride [1629138-41-5(free base)] TGF-beta/Smad
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T2510 Galunisertib LY2157299 TGF-beta/Smad
Galunisertib (LY2157299) is an orally available inhibitor of TGFβRI kinase (IC50: 56 nM) with potential antineoplastic activity.
T1943 ML347 LDN 193719 ALK , TGF-beta/Smad
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T2098 A 77-01 A77-01 ALK , TGF-beta/Smad
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T2109 SD-208 ALK5 Inhibitor V,SD208 TGF-beta/Smad
SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
T5125 LY3200882 TGF-beta/Smad
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T8730 BMS986260 TGF-beta/Smad
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
T2048 LY-364947 LY 364947,HTS466284 MLK , Casein Kinase , TGF-beta/Smad , RIP kinase
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
T3031 A 83-01 ALK5 Inhibitor IV,A8301 ALK , TGF-beta/Smad
A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult...
T1935 LDN193189 LDN-193189,DM-3189,LDN 193189 ALK , TGF-beta/Smad
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
T2386 Pirfenidone S-7701,AMR-69,S-7701,AMR69 CCR , TGF-beta/Smad
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum...
T8330 BIO-013077-01 TGF-beta/Smad
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
T1977 Dorsomorphin Compound C,BML-275 AMPK , Autophagy , TGF-beta/Smad
Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ...
T7799 BMP signaling agonist sb4 SB 4 TGF-beta/Smad
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
T6496 Vactosertib TEW-7197,EW-7197 ALK , TGF-beta/Smad
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...
T1944 LDN-214117 ALK , TGF-beta/Smad
LDN-214117 is a potent and selective ALK2 inhibitor.
T2273 ITD-1 TGF-beta/Smad
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
T1900 LDN-212854 LDN212854,BMP Inhibitor III ALK , TGF-beta/Smad
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.
T6337 RepSox ALK5 Inhibitor II,SJN 2511,E-616452 ALK , TGF-beta/Smad
RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
T1726 SB-431542 SB 431542 ALK , TGF-beta/Smad
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiatio...
T23127 PD-161570 PD 161570 EGFR , FGFR , PDGFR , Src
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...
T9010 IMM-H007 Others , AMPK
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
T6146 Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride AMPK , Autophagy , TGF-beta/Smad
Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
T11052L Disitertide acetate P144 acetate,Disitertide acetate(272105-42-7 Free base) TGF-beta/Smad
Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide acetate is also a PI3K inhibitor and an ...
T2160 Suramin Sodium Salt BAY-205,Suramin hexasodium salt,NF-060 Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T80272 Vicatertide SB-01
Vicatertide is an inhibitor of transforming growth factor beta-1 (TGF-β1) [1].
T79543 J27644 HDAC
J27644 is a potent HDAC (histone deacetylase) inhibitor that mitigates TGF-β (transforming growth factor beta)-induced pulmonary fibrosis [1].
T74204 Trabedersen
Trabedersen (AP 12009), an antisense oligodeoxynucleotide, specifically targets and inhibits TGF-β2 (TGF-beta/Smad), making it useful for researching malignant brain tumors and other solid tumors with high TGF-β2 express...
T24562 NUCC-555
NUCC-555 is a first-in-class antagonist of activin. It opens a completely new approach to inhibiting the activity of TGF-beta receptor superfamily members.
T3689L Ruboxistaurin mesylate LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne...
T69990 Ruboxistaurin mesylate monohydrate
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and...
T79603 3,7-DMF TGF-beta/Smad
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By inducing antioxidant gene expression and scavenging reactive ox...
T75716 Disitertide TFA
Disitertide (P144) TFA is a peptide-based inhibitor of transforming growth factor-beta 1 (TGF-β1), specifically engineered to prevent its interaction with the receptor. Additionally, it functions as a PI3K inhibitor and ...
T75717 Disitertide diammonium
Disitertide (P144) diammonium, a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor, is specifically engineered to prevent its receptor interaction. Additionally, it serves as a PI3K inhibitor and induces apop...
T35438 (5E)-7-Oxozeaenol
(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxoz...

Compounds

SRI-011381
T4283
Synonym:
Target: TGF-beta/Smad
R-268712
T16708
Synonym:
Target: ALK, TGF-beta/Smad
Kartogenin
T1748
Synonym: KGN
Target: TGF-beta/Smad
(E)-SIS3
T3636
Synonym: SIS3,SIS3 HCl
Target: TGF-beta/Smad
BIBF0775
T5197
Synonym:
Target: ALK, TGF-beta/Smad
LY2109761
T2123
Synonym:
Target: Autophagy, TGF-beta/Smad
SJ000291942
T4662
Synonym:
Target: TGF-beta/Smad
GW788388
T1800
Synonym: GW 788388
Target: ALK, TGF-beta/Smad
SB-505124
T2462
Synonym:
Target: ALK, TGF-beta/Smad
SM 16
T4975
Synonym:
Target: ALK, TGF-beta/Smad
SB 525334
T1763
Synonym: SB525334
Target: ALK, TGF-beta/Smad
DMH-1
T1942
Synonym: DMH1
Target: ALK, Autophagy, TGF-beta/Smad
K02288
T1914
Synonym: K 02288
Target: ALK, TGF-beta/Smad
Hydrochlorothiazide
T1449
Synonym: HCTZ
Target: Potassium Channel, Carbonic Anhydrase, TGF-beta/Smad
SRI-011381 hydrochloride
T5129
Synonym: SRI-011381 hydrochloride [1629138-41-5(free base)]
Target: TGF-beta/Smad
Galunisertib
T2510
Synonym: LY2157299
Target: TGF-beta/Smad
ML347
T1943
Synonym: LDN 193719
Target: ALK, TGF-beta/Smad
A 77-01
T2098
Synonym: A77-01
Target: ALK, TGF-beta/Smad
SD-208
T2109
Synonym: ALK5 Inhibitor V,SD208
Target: TGF-beta/Smad
LY3200882
T5125
Synonym:
Target: TGF-beta/Smad
BMS986260
T8730
Synonym:
Target: TGF-beta/Smad
LY-364947
T2048
Synonym: LY 364947,HTS466284
Target: MLK, Casein Kinase, TGF-beta/Smad, RIP kinase
A 83-01
T3031
Synonym: ALK5 Inhibitor IV,A8301
Target: ALK, TGF-beta/Smad
LDN193189
T1935
Synonym: LDN-193189,DM-3189,LDN 193189
Target: ALK, TGF-beta/Smad
Pirfenidone
T2386
Synonym: S-7701,AMR-69,S-7701,AMR69
Target: CCR, TGF-beta/Smad
BIO-013077-01
T8330
Synonym:
Target: TGF-beta/Smad
Dorsomorphin
T1977
Synonym: Compound C,BML-275
Target: AMPK, Autophagy, TGF-beta/Smad
BMP signaling agonist sb4
T7799
Synonym: SB 4
Target: TGF-beta/Smad
Vactosertib
T6496
Synonym: TEW-7197,EW-7197
Target: ALK, TGF-beta/Smad
LDN-214117
T1944
Synonym:
Target: ALK, TGF-beta/Smad
ITD-1
T2273
Synonym:
Target: TGF-beta/Smad
LDN-212854
T1900
Synonym: LDN212854,BMP Inhibitor III
Target: ALK, TGF-beta/Smad
RepSox
T6337
Synonym: ALK5 Inhibitor II,SJN 2511,E-616452
Target: ALK, TGF-beta/Smad
SB-431542
T1726
Synonym: SB 431542
Target: ALK, TGF-beta/Smad
PD-161570
T23127
Synonym: PD 161570
Target: EGFR, FGFR, PDGFR, Src
IMM-H007
T9010
Synonym:
Target: Others, AMPK
Dorsomorphin dihydrochloride
T6146
Synonym: BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride
Target: AMPK, Autophagy, TGF-beta/Smad
Disitertide acetate
T11052L
Synonym: P144 acetate,Disitertide acetate(272105-42-7 Free base)
Target: TGF-beta/Smad
Suramin Sodium Salt
T2160
Synonym: BAY-205,Suramin hexasodium salt,NF-060
Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite
Vicatertide
T80272
Synonym: SB-01
Target:
J27644
T79543
Synonym:
Target: HDAC
Trabedersen
T74204
Synonym:
Target:
NUCC-555
T24562
Synonym:
Target:
Ruboxistaurin mesylate
T3689L
Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Target:
Ruboxistaurin mesylate monohydrate
T69990
Synonym:
Target:
3,7-DMF
T79603
Synonym:
Target: TGF-beta/Smad
Disitertide TFA
T75716
Synonym:
Target:
Disitertide diammonium
T75717
Synonym:
Target:
(5E)-7-Oxozeaenol
T35438
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TQ0184 Chebulinic acid ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T13741 Isoviolanthin Others
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat...
TN2081 Maohuoside A MAPK
Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
T2754 Oxymatrine Oxysophoridine,Matrine N-oxide Influenza Virus , Autophagy , TGF-beta/Smad
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.It can also inhibit iNOS expressio...
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T5247 Trimethylamine N-oxide dihydrate TMANO Dihydrate Others , Endogenous Metabolite
Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.
T2896 Alantolactone helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor Apoptosis , STAT , TGF-beta/Smad
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3...
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T3025 Asiaticoside BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,NSC166062 Apoptosis , p38 MAPK , Reactive Oxygen Species , Endogenous Metabolite , TGF-beta/Smad
Asiaticoside (Emdecassol) (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
TN1471 Cassiaside C Toralactone 9-O-β-D-gentiobioside Others , Endogenous Metabolite
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE).
TN2165 Rubrofusarin gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside ERK , NF-κB , TGF-beta/Smad
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive...

Natural Products

Chebulinic acid
TQ0184
Synonym:
Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad
Isoviolanthin
T13741
Synonym:
Target: Others
Maohuoside A
TN2081
Synonym:
Target: MAPK
Oxymatrine
T2754
Synonym: Oxysophoridine,Matrine N-oxide
Target: Influenza Virus, Autophagy, TGF-beta/Smad
Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Trimethylamine N-oxide dihydrate
T5247
Synonym: TMANO Dihydrate
Target: Others, Endogenous Metabolite
Alantolactone
T2896
Synonym: helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,Inula camphor
Target: Apoptosis, STAT, TGF-beta/Smad
Halofuginone hydrobromide
T3524
Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Asiaticoside
T3025
Synonym: BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,NSC166062
Target: Apoptosis, p38 MAPK, Reactive Oxygen Species, Endogenous Metabolite, TGF-beta/Smad
Cassiaside C
TN1471
Synonym: Toralactone 9-O-β-D-gentiobioside
Target: Others, Endogenous Metabolite
Rubrofusarin gentiobioside
TN2165
Synonym: Rubrofusarin-6-O-beta-D-gentiobioside
Target: ERK, NF-κB, TGF-beta/Smad

Recombinant Proteins

Species：
Human (90)
Mouse (44)
Cynomolgus (10)
Canine (7)
Rat (6)
Bovine (3)
Mouse,Rat (3)
Human,Mouse,Rat (2)
Human,Mouse,Rat,Rhesus,Canine (2)
Rhesus (2)
Expression System：
HEK293 (89)
E. coli (40)
Human Cells (31)
Baculovirus-Insect Cells (11)
Baculovirus (4)
CHO (1)
Yeast (1)
Tag：
His (49)
hFc (24)
His,hFc (9)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (9)
N-terminal 6xHis-tagged (9)
Tag Free (9)
N-His (6)
N-hFc (6)
C-Fc (5)
His,GST (5)
Cat No. Product Name Species Expression System
TMPY-00413 TGF beta 2 Protein, Mouse, Recombinant (His) Mouse HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-06247 TGF beta 3 Protein, Human, Recombinant (hFc) Human HEK293
TGF beta 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 41.2 kDa. Accession number: P10600-1
TMPY-01133 Latent TGF beta 1 Protein, Human, Recombinant (His) Human HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00258 TGF beta 2 Protein, Human, Recombinant Human Human Cells
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. T...
TMPJ-00249 TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-...
TMPJ-00254 TGF beta 3 Protein, Human/Mouse/Rat, Recombinant Human,Mouse,Rat Human Cells
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes acti...
TMPY-00500 Latent TGF beta 1 Protein, Mouse, Recombinant (His) Mouse HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00261 TGF beta 2 Protein, Mouse/Rat, Recombinant Mouse,Rat Human Cells
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci...
TMPY-00608 TGF beta 1 Protein, Rat/Mouse, Recombinant Mouse,Rat HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPY-03945 Latent TGF beta 1 Protein, Rat, Recombinant (His) Rat HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPY-04211 Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPY-02638 TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant Human,Rhesus,Cynomolgus,Canine CHO
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant Mouse,Rat Human Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differen...
TMPY-04577 TGF beta 2 Protein, Rhesus, Recombinant (His) Rhesus HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-00231 TGF beta 2 Protein, Canine, Recombinant (His) Canine HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-05314 TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated Mouse HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPJ-00335 TGFBR2 Protein, Mouse, Recombinant (His) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPJ-00256 Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPK-00258 Latent TGF beta 3 Protein, Human, Recombinant (His) Human HEK293
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differen...
TMPY-05521 Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated Human HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00260 Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPK-01243 GDF-15 Protein, Rat, Recombinant (His) Rat E. coli
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GD...
TMPK-01246 GDF-15 Protein, Mouse, Recombinant (His) Mouse E. coli
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPY-05313 Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated Mouse HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPK-00259 Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differen...
TMPJ-00250 LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activ...
TMPK-00305 TGFBR1 Protein, Human, Recombinant (mFc & Avi) Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-00229 Latent TGF beta 1 Protein, Canine, Recombinant (His) Canine HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00622 Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) Cynomolgus Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00259 TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00772 Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPH-00305 TGF-beta 1 Protein, Bovine, Recombinant (His) Bovine E. coli
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1,...
TMPH-00306 TGF-beta 2 Protein, Bovine, Recombinant (His & Myc) Bovine E. coli
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2,...
TMPJ-00255 TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPH-00382 TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO) Chicken E. coli
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1,...
TMPJ-00334 TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPJ-00333 TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPK-00197 GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated Human HEK293
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPK-01244 GDF-15 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPK-00569 GDF-15 Protein, Canine, Recombinant (His) Canine E. coli
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GD...
TMPK-00665 GDF-15 Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPK-00196 GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated Human E. coli
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GD...
TMPK-00664 GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated Cynomolgus HEK293
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPK-00198 GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated Human HEK293
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPY-06355 Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) Human HEK293
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 108.72 kDa. Accession number: P01137
TMPK-01245 GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated Mouse HEK293
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPK-00663 GDF-15 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t...
TMPK-00306 TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPJ-00290 GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) Human Human Cells
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two s...
TMPJ-01178 TGFBR1 Protein, Mouse, Recombinant (hFc) Mouse Human Cells
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho...
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TGF beta 2 Protein, Mouse, Recombinant (His)
TMPY-00413
Species: Mouse
Expression System: HEK293
TGF beta 3 Protein, Human, Recombinant (hFc)
TMPY-06247
Species: Human
Expression System: HEK293
Latent TGF beta 1 Protein, Human, Recombinant (His)
TMPY-01133
Species: Human
Expression System: HEK293
TGF beta 2 Protein, Human, Recombinant
TMPJ-00258
Species: Human
Expression System: Human Cells
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00249
Species: Human
Expression System: Human Cells
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
TMPJ-00254
Species: Human,Mouse,Rat
Expression System: Human Cells
Latent TGF beta 1 Protein, Mouse, Recombinant (His)
TMPY-00500
Species: Mouse
Expression System: HEK293
TGF beta 2 Protein, Mouse/Rat, Recombinant
TMPJ-00261
Species: Mouse,Rat
Expression System: Human Cells
TGF beta 1 Protein, Rat/Mouse, Recombinant
TMPY-00608
Species: Mouse,Rat
Expression System: HEK293
Latent TGF beta 1 Protein, Rat, Recombinant (His)
TMPY-03945
Species: Rat
Expression System: HEK293
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
TMPY-04211
Species: Cynomolgus
Expression System: HEK293
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
TMPY-02638
Species: Human,Rhesus,Cynomolgus,Canine
Expression System: CHO
TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Species: Mouse,Rat
Expression System: Human Cells
TGF beta 2 Protein, Rhesus, Recombinant (His)
TMPY-04577
Species: Rhesus
Expression System: HEK293
TGF beta 2 Protein, Canine, Recombinant (His)
TMPY-00231
Species: Canine
Expression System: HEK293
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
TMPY-05314
Species: Mouse
Expression System: HEK293
TGFBR2 Protein, Mouse, Recombinant (His)
TMPJ-00335
Species: Mouse
Expression System: Human Cells
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00256
Species: Human
Expression System: Human Cells
Latent TGF beta 3 Protein, Human, Recombinant (His)
TMPK-00258
Species: Human
Expression System: HEK293
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
TMPY-05521
Species: Human
Expression System: HEK293
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00260
Species: Human
Expression System: Human Cells
GDF-15 Protein, Rat, Recombinant (His)
TMPK-01243
Species: Rat
Expression System: E. coli
GDF-15 Protein, Mouse, Recombinant (His)
TMPK-01246
Species: Mouse
Expression System: E. coli
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
TMPY-05313
Species: Mouse
Expression System: HEK293
Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00259
Species: Human
Expression System: HEK293
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00250
Species: Human
Expression System: Human Cells
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
TMPK-00305
Species: Human
Expression System: HEK293
Latent TGF beta 1 Protein, Canine, Recombinant (His)
TMPY-00229
Species: Canine
Expression System: HEK293
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
TMPJ-00622
Species: Cynomolgus
Expression System: Human Cells
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00259
Species: Human
Expression System: Human Cells
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPJ-00772
Species: Mouse
Expression System: Human Cells
TGF-beta 1 Protein, Bovine, Recombinant (His)
TMPH-00305
Species: Bovine
Expression System: E. coli
TGF-beta 2 Protein, Bovine, Recombinant (His & Myc)
TMPH-00306
Species: Bovine
Expression System: E. coli
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00255
Species: Human
Expression System: Human Cells
TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO)
TMPH-00382
Species: Chicken
Expression System: E. coli
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
TMPJ-00334
Species: Mouse
Expression System: Human Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
TMPJ-00333
Species: Mouse
Expression System: Human Cells
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
TMPK-00197
Species: Human
Expression System: HEK293
GDF-15 Protein, Mouse, Recombinant (hFc)
TMPK-01244
Species: Mouse
Expression System: HEK293
GDF-15 Protein, Canine, Recombinant (His)
TMPK-00569
Species: Canine
Expression System: E. coli
GDF-15 Protein, Cynomolgus, Recombinant (His)
TMPK-00665
Species: Cynomolgus
Expression System: E. coli
GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00196
Species: Human
Expression System: E. coli
GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
TMPK-00664
Species: Cynomolgus
Expression System: HEK293
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
TMPK-00198
Species: Human
Expression System: HEK293
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
TMPY-06355
Species: Human
Expression System: HEK293
GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
TMPK-01245
Species: Mouse
Expression System: HEK293
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
TMPK-00663
Species: Cynomolgus
Expression System: HEK293
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TMPK-00306
Species: Human
Expression System: HEK293
GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
TMPJ-00290
Species: Human
Expression System: Human Cells
TGFBR1 Protein, Mouse, Recombinant (hFc)
TMPJ-01178
Species: Mouse
Expression System: Human Cells
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Cat No. Product Name
L4100 TGF-beta/Smad Compound Library

184 compounds
A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
L9810 Anti-Fibrosis Compound Library

1155 compounds
A unique collection of 1155 potential anti-fibrosis compounds, can be used in HTS and HCS;

Libraries

TGF-beta/Smad Compound Library
L4100
Compounds: 184
Anti-Fibrosis Compound Library
L9810
Compounds: 1155
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