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Hydrochlorothiazide

Catalog No. T1449   CAS 58-93-5
Synonyms: HCTZ

Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.

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Hydrochlorothiazide Chemical Structure
Hydrochlorothiazide, CAS 58-93-5
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500 mg In stock $ 41.00
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Purity: 99.9%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
Kinase Assay Kinase autophosphorylation assays: Kinase assays using wild-type and mutant glutathione S-transferase (GST)-Abl fusion proteins (c-Abl amino acids 220-498) are done. GST-Abl fusion proteins are released from glutathione-Sepharose beads before use; the concentration of ATP is 5 μM. Immediately before use in kinase autophosphorylation and in vitro peptide substrate phosphorylation assays, GST-Abl kinase domain fusion proteins are treated with LAR tyrosine phosphatase. After 1-hour incubation at 30 °C, LAR phosphatase is inactivated by addition of sodium vanadate (1 mM). Immunoblot analysis comparing untreated GST-Abl kinase to dephosphorylated GST-Abl kinase is routinely done using phosphotyrosine-specific antibody 4 g10 to confirm complete (>95%) dephosphorylation of tyrosine residues and c-Abl antibody CST 2862 to confirm equal loading of GST-Abl kinase. The Dasatinib concentration range is extended to 1,000 nM for mutant T315I. These same inhibitor concentrations are used for the in vitro peptide substrate phosphorylation assays. The three inhibitors are tested over these same concentration ranges against GST-Src kinase and GST-Lyn kinase.
Synonyms HCTZ
Molecular Weight 297.74
Formula C7H8ClN3O4S2
CAS No. 58-93-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 20 mg/mL(67.2 mM)

TargetMolReferences and Literature

1. Ran XW, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul; 36(4):583-7.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Fibrosis Compound Library Anti-Hypertension Compound Library Cancer Cell Differentiation Compound Library Reprogramming Compound Library Potassium Channel Blocker Library Drug-Fragment Library

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Keywords

Hydrochlorothiazide 58-93-5 Membrane transporter/Ion channel Metabolism Stem Cells Carbonic Anhydrase TGF-beta/Smad Potassium Channel relaxant HCTZ calcium KcsA fibrosis potassium vascular antihypertensive KCA Transforming growth factor beta inhibit cardiac Inhibitor inhibitor

 

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