GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 932.00
500 μg	5 days	$ 3,720.00
1 mg	5 days	$ 6,210.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 932.00

500 μg

5 days

$ 3,720.00

1 mg

5 days

$ 6,210.00

Description

Species	Human
Expression System	HEK293
Tag	N-hFc
Accession Number	Q99988
Synonyms	Placental TGF-β, GDF15, RG-1, MIC-1, PTGFB, PTGF-beta, PDF, PTGF-β, PTGFBPTGF-β, NAG-1, PTGFBPTGF-beta, PLAB, MIC1, GDF-15, Placental TGF-beta
Construction	Recombinant Biotinylated Human GDF15 (H202D) Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the N-terminus. It contains Ala197-Ile308 (H202D).[Accession \|Q99988]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 37.88 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.