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SJ000291942

Catalog No. T4662   CAS 425613-09-8

SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.

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SJ000291942 Chemical Structure
SJ000291942, CAS 425613-09-8
Pack Size Availability Price/USD Quantity
2 mg In stock $ 38.00
5 mg In stock $ 61.00
10 mg In stock $ 107.00
25 mg In stock $ 243.00
50 mg In stock $ 423.00
100 mg In stock $ 627.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Purity: 99.07%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
In vitro SJ000291942 is the most potent compound in causing severe ventralization in embryos, displaying higher mortality rates at lower doses compared to controls and two other compounds, indicating its strong induction of ventralization through enhanced BMP signaling activity. It elevates bmp2b and szl expression levels, suggesting activation of the canonical BMP signaling pathway in zebrafish assays. Further, immunoblotting experiments on C33A-2D2 cell lysates treated with SJ000291942 show its ability to activate SMAD1/5/8 phosphorylation within 1 hour in a serum-free medium, mirroring its high activity observed in zebrafish. Additionally, SJ000291942 significantly induces phosphorylation of Extracellular Signal-regulated Kinase, ERK1/2 (P-ERK1/2). High doses of BMP4 treatments (100 and 300ng) result in a gene expression profile similar to that of osteoblasts, while a low dose (10ng) of BMP4 closely matches the effects observed with 25μM of both compound 3 and SJ000291942 treatments.
Molecular Weight 318.3
Formula C16H15FN2O4
CAS No. 425613-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL

TargetMolReferences and Literature

1. Genthe JR, et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol. 2017 Sep 15;12(9):2436-2447.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Lung Cancer Compound Library Stem Cell Differentiation Compound Library Anti-Cardiovascular Disease Compound Library HIF-1 Signaling Pathway Compound Library Cytokine Inhibitor Library Anti-Colorectal Cancer Compound Library Anti-Fibrosis Compound Library NO PAINS Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library

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Keywords

SJ000291942 425613-09-8 Stem Cells TGF-beta/Smad Transforming growth factor beta receptors SJ 000291942 TGF-β Receptor inhibit SJ-000291942 Inhibitor inhibitor

 

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