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ML347

Catalog No. T1943 CAS 1062368-49-3

Synonyms: LDN 193719

ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is <300-fold than ALK3.

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ML347, CAS 1062368-49-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 52.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 159.00
50 mg	In stock	$ 288.00
100 mg	In stock	$ 490.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.71%

Purity: 98.3%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
Targets&IC50	ALK1:46 nM, ALK2:32 nM
In vivo	In both human and rat plasma, ML347 exhibits high binding affinity with plasma proteins. Additionally, ML347 demonstrates significant efficacy in C2C12BRA cells responsive to BMP signaling, evidenced by an IC50 value of 15 nM.
Kinase Assay	Kinase assay: All kinase assays are conducted by Reaction Biology Corp. In brief, compounds are tested at 10 concentrations by 3-fold serial dilutions starting at 30 μM, using nonspecific kinase inhibitor staurosporine as control. In vitro kinase reactions are carried out in the presence of 10 μM (33P)γATP. Five kinases tested are the human BMP type-I receptor activin receptor-like kinase 2 (ALK-2/ACVR1), the human TGFβ type-I receptor activin receptor-like kinase 5 (Alk5/TGFβR1), the human VEGF type-II receptor (KDR/Flk-1/VEGFR2), the human AMP-activated protein kinase (AMPK/A1/B1/G1) and the human platelet-derived growth factor receptor-β (PDGFRβ).

Synonyms	LDN 193719
Molecular Weight	352.39
Formula	C22H16N4O
CAS No.	1062368-49-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.1 mg/mL (20 mM)

References and Literature

1. Engers DW, et al. Bioorg Med Chem Lett. 2013, 23(11), 3248-3252.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library TGF-beta/Smad Compound Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Anti-Fibrosis Compound Library Anti-Obesity Compound Library Anti-Aging Compound Library Anti-Colorectal Cancer Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

K02288 Lorlatinib BIBF0775 Entrectinib KRCA-0008 ZX-29 LDN-193189 2HCl ALK-IN-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML347 1062368-49-3 Angiogenesis Stem Cells Tyrosine Kinase/Adaptors ALK TGF-beta/Smad Inhibitor Smad1/5 inhibit LDN 193719 LDN-193719 LDN193719 TGF-β Receptor ML 347 Transforming growth factor beta receptors ALK1 ML-347 ALK2 inhibitor

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