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LY3200882

Catalog No. T5125   CAS 1898283-02-7

LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).

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LY3200882 Chemical Structure
LY3200882, CAS 1898283-02-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 45.00
2 mg In stock $ 64.00
5 mg In stock $ 107.00
10 mg In stock $ 169.00
25 mg In stock $ 317.00
50 mg In stock $ 513.00
100 mg In stock $ 743.00
500 mg In stock $ 1,550.00
1 mL * 10 mM (in DMSO) In stock $ 118.00
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Purity: 99.46%
Purity: 98.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
Targets&IC50 TGF-β receptor type 1 (ALK5):38.2 nM (IC50)
In vitro LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells. LY3200882 has shown anti-metastatic activity in vitro in migration assays. In in vitro immune suppression assays, LY3200882 has shown the ability to rescue TGFβ1 suppressed or T regulatory cell suppressed na?ve T cell activity and restore proliferation [1].
In vivo LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose-dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer) [1].
Molecular Weight 435.52
Formula C24H29N5O3
CAS No. 1898283-02-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 85 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Huaxing Pei, et al. Abstract 955: LY3200882, a novel, highly selective TGFβRI small molecule inhibitor. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 955.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Liver Cancer Compound Library Cytokine Inhibitor Library Anti-Aging Compound Library Bioactive Compounds Library Max Bioactive Compound Library ReFRAME Related Library

Related Products

Related compounds with same targets
SRI-011381 3,7-DMF DT-6 Nisevokitug Myristoyl tetrapeptide-12 SIS3 free base Dalbergioidin TGFβRI-IN-1

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Keywords

LY3200882 1898283-02-7 Stem Cells TGF-beta/Smad Anti-cancer ALK5 TGFβRI ATP-competitive inhibit immune phosphorylation Transforming growth factor beta receptors anti-metastatic TGF-β Receptor LY-3200882 SMAD serine-threonine Inhibitor LY 3200882 inhibitor

 

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