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Kartogenin

Kartogenin
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Purity:97.79%
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Kartogenin

Catalog No. T1748Cas No. 4727-31-5
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
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Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$46In Stock
10 mg$53In Stock
25 mg$91In Stock
50 mg$166In Stock
100 mg$288In Stock
1 mL x 10 mM (in DMSO)$51In Stock
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Product Introduction

Bioactivity
Description
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
In vitro
Kartogenin promotes type I collagen synthesis in dermal fibroblasts by activating the Smad4/Smad5 pathway, without exhibiting significant cytotoxicity on the activity, morphology, and survival of fibroblasts. Additionally, by enhancing the nuclear localization of CBFβ, Kartogenin induces differentiation of hMSCs into chondrocytes and protects articular chondrocytes.
In vivo
Kartogenin at a concentration of 100 nM stimulates collagen synthesis in the dermis of mice. Additionally, it promotes the growth of skeletal limbs and the development of synovial joints in mice. Concentrations of 10 μM and 100 μM Kartogenin respectively enhance cartilage repair in mouse models of osteoarthritis (OA) induced by collagenase VII and surgically.
Cell Research
For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer's instructions, cell viability and viability are assessed by AlamarBlue assay.(Only for Reference)
AliasKGN
Chemical Properties
Molecular Weight317.34
FormulaC20H15NO3
Cas No.4727-31-5
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: <1 mg/mL
DMSO: 63 mg/mL (198.52 mM)
Ethanol: 18 mg/mL (56.72 mM), Heating is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.1512 mL15.7560 mL31.5119 mL157.5597 mL
5 mM0.6302 mL3.1512 mL6.3024 mL31.5119 mL
10 mM0.3151 mL1.5756 mL3.1512 mL15.7560 mL
20 mM0.1576 mL0.7878 mL1.5756 mL7.8780 mL
50 mM0.0630 mL0.3151 mL0.6302 mL3.1512 mL
DMSO
1mg5mg10mg50mg
100 mM0.0315 mL0.1576 mL0.3151 mL1.5756 mL

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