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Kartogenin

Catalog No. T1748 CAS 4727-31-5

Synonyms: KGN

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal <a href="/pathway/Stem_Cells" style="display: inline; color: #c13a36">Stem Cells</a> into chondrocytes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Kartogenin, CAS 4727-31-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 50.00
10 mg	In stock	$ 53.00
25 mg	In stock	$ 91.00
50 mg	In stock	$ 166.00
100 mg	In stock	$ 288.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 96.25%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
Cell Research	For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer's instructions, cell viability and viability are assessed by AlamarBlue assay.(Only for Reference)

Synonyms	KGN
Molecular Weight	317.344
Formula	C20H15NO3
CAS No.	4727-31-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 63 mg/mL (198.52 mM)

Ethanol: 18 mg/mL (56.72 mM), warmed

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Johnson K, et al. Science. 2012, 336(6082), 717-721. 2. Wang J, et al. Biochem Biophys Res Commun. 2014, 450(1), 568-574. 3. Decker RS, et al. Dev Biol. 2014, 395(2), 255-267.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Fibrosis Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Cytokine Inhibitor Library Cancer Cell Differentiation Compound Library Immunology/Inflammation Compound Library HIF-1 Signaling Pathway Compound Library Stem Cell Differentiation Compound Library Reprogramming Compound Library Anti-Cardiovascular Disease Compound Library

Related Products

Related compounds with same targets

Dalbergioidin TGFβRI-IN-3 LSKL, Inhibitor of Thrombospondin TSP-1 acetate LSKL, Inhibitor of Thrombospondin (TSP-1) Chromenone 1 LDN-193189 2HCl TP0427736 Pentabromophenol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Kartogenin 4727-31-5 Stem Cells TGF-beta/Smad Inhibitor stem chondrocytes KGN human differentiation inhibit mesenchymal Transforming growth factor beta cells osteoarthritis inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.