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LDN-212854

Catalog No. T1900 CAS 1432597-26-6

Synonyms: LDN212854, BMP Inhibitor III

LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.

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LDN-212854, CAS 1432597-26-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 42.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 185.00
25 mg	In stock	$ 372.00
50 mg	In stock	$ 556.00
100 mg	In stock	$ 783.00

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Purity: 99.38%

Purity: 98%

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Description	LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.
Targets&IC50	ALK2:1.3 nM
In vitro	LDN-212854 (6 mg/kg, i.p.) effectively inactivates ALK2 signaling in vivo and efficiently inhibits ectopic ossification in inducible transgenic ALK2 mice mutants with progressive ankylosis.
In vivo	In C2C12 myoblasts, LDN-212854 demonstrates a higher selectivity for BMP6 over BMP4 in inducing osteogenic differentiation, compared to the osteogenic differentiation induced by BMP6 and BMP4.

Synonyms	LDN212854, BMP Inhibitor III
Molecular Weight	406.48
Formula	C25H22N6
CAS No.	1432597-26-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

2eq.HCl: 20.3 mg/mL (50 mM)

References and Literature

1. ACS Chem Biol. 2013, 8(6), 1291-1302. 2. Yuan Q, Cao S, Dong Q, et al. ALDH2 Activation Inhibited Cardiac Fibroblast-to-Myofibroblast Transformation Via the TGF-β1/Smad Signaling Pathway[J]. Journal of cardiovascular pharmacology. 2019 Apr;73(4): 248-256.

Citations

1. Yuan Q, Cao S, Dong Q, et al. ALDH2 Activation Inhibited Cardiac Fibroblast-to-Myofibroblast Transformation Via the TGF-β1/Smad Signaling Pathway. Journal of cardiovascular pharmacology. 2019 Apr;73(4): 248-256.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library TGF-beta/Smad Compound Library Kinase Inhibitor Library Immuno-Oncology Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Cancer Cell Differentiation Compound Library Angiogenesis related Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LDN-212854 1432597-26-6 Angiogenesis Stem Cells Tyrosine Kinase/Adaptors TGF-beta/Smad ALK LDN212854 HCC Huh7 EpCAM Inhibitor BMP BMP Inhibitor III Transforming growth factor beta receptors BMP9-ID1 signaling MT cell heterotopic ossification FOP model TGF-β Receptor LDN 212854 inhibit BMPR2 cell inhibitor

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