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Alantolactone

Alantolactone
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Purity:99.91%
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Alantolactone

Catalog No. T2896Cas No. 546-43-0
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.
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Pack SizePriceAvailabilityQuantity
5 mg$50In Stock
10 mg$65In Stock
25 mg$144In Stock
50 mg$233In Stock
100 mg$420In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Product Introduction

Bioactivity
Description
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.
In vitro
Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Alantolactone effectively suppressed both constitutive and inducible STAT3 activation at tyrosine 705. It decreased STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases. SHP-1, SHP-2, and PTEN, which are protein tyrosine phosphatases (PTPs) were not affected by alantolactone. Alantolactone treatment resulted in the inhibition of migration, invasion, adhesion, and colony formation[1]. Alantolactone could induce activin signaling and activin target gene expression. Alantolactone activated the activin signaling pathway in a cancer cell line. It could promote SMAD2/3 nuclear translocation in a very short time[3].
In vivo
In vivo administration of alantolactone inhibited the growth of human breast xenograft tumors[1]. Alantolactone exerts no toxic effect on liver and kidneys in vivo, The drug was well tolerated by mice and no mortality or any sign of pharmacotoxicity was found at a dose of 100 mg/kg during all the experimental periods. Alantolactone can cross blood-brain barrier[2].
Cell Research
Cell viability was evaluated using MTT assay. The cells were seeded into 96-well plates and maintained at 37 °C for 24 h. The cells were treated with alantolactone for 24 h. The MTT solution (0.5 mg/mL) was added to each well, and the cells were incubated for another 3 h. The MTT formazan crystals were dissolved in DMSO. The results were obtained by measuring the absorbance at a wavelength of 540 nm using a microplate reader.(Only for Reference)
Aliashelenin, Eupatal, Helenine, (+)-Alantolactone, Alant camphor, Inula camphor
Chemical Properties
Molecular Weight232.32
FormulaC15H20O2
Cas No.546-43-0
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 23.2 mg/mL (100 mM)
Ethanol: 46 mg/mL (198 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.3044 mL21.5220 mL43.0441 mL215.2204 mL
5 mM0.8609 mL4.3044 mL8.6088 mL43.0441 mL
10 mM0.4304 mL2.1522 mL4.3044 mL21.5220 mL
20 mM0.2152 mL1.0761 mL2.1522 mL10.7610 mL
50 mM0.0861 mL0.4304 mL0.8609 mL4.3044 mL
100 mM0.0430 mL0.2152 mL0.4304 mL2.1522 mL

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