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PD-161570

Catalog No. T23127 CAS 192705-80-9

Synonyms: PD 161570

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.

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PD-161570, CAS 192705-80-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
Targets&IC50	FGFR1:39.9 nM (IC50), FGFR1 autophosphorylation:622 nM, FGFR1:42 nM (Ki)

Synonyms	PD 161570
Molecular Weight	532.51
Formula	C26H35Cl2N7O
CAS No.	192705-80-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/ml (56.34 mM), Need ultrasonic

Ethanol: <53.25mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hamby JM, et al. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem. 1997 Jul 18;40(15):2296-303.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PD-161570 192705-80-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors Src EGFR FGFR PDGFR Inhibitor Fibroblast growth factor receptor HER1 kinases PD 161570 autophosphorylation PD161570 inhibit TGF-β Receptor ATP-competitive Epidermal growth factor receptor tyrosine Platelet-derived growth factor receptor disease anti-cancer angiogenesis ErbB-1 FGFR1 Transforming growth factor beta receptors cardiovascular anti-proliferation inhibitor

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