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Catalog No. T2109   CAS 627536-09-8
Synonyms: SD208, ALK5 Inhibitor V

SD-208, a selective TGF-βRI (<a href="/target/ALK" style="display: inline; color: #c13a36">ALK</a>5) inhibitor (IC50: 48 nM), is &gt;100-fold selectivity over TGF-βRII.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SD-208, CAS 627536-09-8
Pack Size Availability Price/USD Quantity
2 mg In stock $ 50.00
5 mg In stock $ 73.00
10 mg In stock $ 103.00
25 mg In stock $ 216.00
100 mg In stock $ 511.00
1 mL * 10 mM (in DMSO) In stock $ 114.00
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Purity: 98.72%
Purity: 98%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
Targets&IC50 TGF-βRI (ALK5):48 nM
Kinase Assay Kinase assay: Various kinase activities are assayed by measuring the incorporation of radiolabeled ATP into a peptide or protein substrate. The reactions are performed in 96-well plates and included the relevant kinase, substrate, ATP, and appropriate cofactors. The reactions are incubated and then stopped by the addition of phosphoric acid. Substrate is captured onto a phosphocellulose filter, which is washed free of unreacted ATP. The counts incorporated are determined by counting on a microplate scintillation counter. The ability of SD-208 to inhibit the respective kinase is determined by comparing counts incorporated in the presence of compound with those incorporated in the absence of compound.
Cell Research Glioma cells are cultured in the absence or presence of SD-208 (1 μM) for 48 hours. The cells are pulsed for the last 24 hours with [methyl-3H]thymidine (0.5 μCi) and harvested, and incorporated radioactivity is determined in a liquid scintillation counter.(Only for Reference)
Synonyms SD208, ALK5 Inhibitor V
Molecular Weight 352.76
Formula C17H10ClFN6
CAS No. 627536-09-8


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 7.1 mg/mL (20 mM)), with gentle warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Uhl M, et al. Cancer Res. 2004, 64(21), 7954-7961. 2. Ge R, et al. Clin Cancer Res. 2006, 12(14 Pt 1), 4315-4330. 3. Sun Y, et al. J Heart Lung Transplant. 2014, 33(6), 654-661.

Related compound libraries

This product is contained In the following compound libraries:
Fluorochemical Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max Anti-Cancer Active Compound Library Immuno-Oncology Compound Library Anti-Cancer Compound Library Target-Focused Phenotypic Screening Library Kinase Inhibitor Library Bioactive Compound Library TGF-beta/Smad Compound Library

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SD-208 627536-09-8 Stem Cells TGF-beta/Smad SD208 inhibit Transforming growth factor beta receptors TGF-β Receptor Inhibitor SD 208 ALK5 Inhibitor V inhibitor