Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SD-208, a selective TGF-βRI (<a href="/target/ALK" style="display: inline; color: #c13a36">ALK</a>5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 73.00 | |
10 mg | In stock | $ 103.00 | |
25 mg | In stock | $ 216.00 | |
100 mg | In stock | $ 511.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 114.00 |
Description | SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII. |
Targets&IC50 | TGF-βRI (ALK5):48 nM |
Kinase Assay | Kinase assay: Various kinase activities are assayed by measuring the incorporation of radiolabeled ATP into a peptide or protein substrate. The reactions are performed in 96-well plates and included the relevant kinase, substrate, ATP, and appropriate cofactors. The reactions are incubated and then stopped by the addition of phosphoric acid. Substrate is captured onto a phosphocellulose filter, which is washed free of unreacted ATP. The counts incorporated are determined by counting on a microplate scintillation counter. The ability of SD-208 to inhibit the respective kinase is determined by comparing counts incorporated in the presence of compound with those incorporated in the absence of compound. |
Cell Research | Glioma cells are cultured in the absence or presence of SD-208 (1 μM) for 48 hours. The cells are pulsed for the last 24 hours with [methyl-3H]thymidine (0.5 μCi) and harvested, and incorporated radioactivity is determined in a liquid scintillation counter.(Only for Reference) |
Synonyms | SD208, ALK5 Inhibitor V |
Molecular Weight | 352.76 |
Formula | C17H10ClFN6 |
CAS No. | 627536-09-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 7.1 mg/mL (20 mM)), with gentle warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SD-208 627536-09-8 Stem Cells TGF-beta/Smad SD208 inhibit Transforming growth factor beta receptors TGF-β Receptor Inhibitor SD 208 ALK5 Inhibitor V inhibitor