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SRI-011381 hydrochloride

SRI-011381 hydrochloride
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SRI-011381 hydrochloride

Catalog No. T5129Cas No. 2070014-88-7
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$64In Stock
10 mg$113In Stock
25 mg$239In Stock
50 mg$397In Stock
100 mg$589In Stock
500 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Product Introduction

SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
In vitro
SRI-11381 is neuroprotective. SRI-011381 promote fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
In vivo
SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (i.p.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells, hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
AliasSRI-011381 hydrochloride [1629138-41-5(free base)]
Chemical Properties
Molecular Weight365.94
Cas No.2070014-88-7
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 12 mg/mL (32.79 mM)
H2O: 76.92 mg/mL (210 mM), Sonication is recommended.
Solution Preparation Table
1 mM2.7327 mL13.6634 mL27.3269 mL136.6344 mL
5 mM0.5465 mL2.7327 mL5.4654 mL27.3269 mL
10 mM0.2733 mL1.3663 mL2.7327 mL13.6634 mL
20 mM0.1366 mL0.6832 mL1.3663 mL6.8317 mL
50 mM0.0547 mL0.2733 mL0.5465 mL2.7327 mL
100 mM0.0273 mL0.1366 mL0.2733 mL1.3663 mL


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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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