Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 157.00 | |
10 mg | In stock | $ 230.00 | |
25 mg | In stock | $ 490.00 | |
50 mg | In stock | $ 728.00 | |
100 mg | In stock | $ 987.00 | |
500 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 280.00 |
Description | Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. |
Targets&IC50 | H+, K+-ATPase:IC50 : 65.01 μg/ml |
In vitro | Chebulinic acid obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of Chebulinic acid inhibited HQ/Cu(II)-mediated double-strand breaks of genomic DNA [1]. |
In vivo | Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L [2]. |
Source |
Molecular Weight | 956.68 |
Formula | C41H32O27 |
CAS No. | 18942-26-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (28.75 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Chebulinic acid 18942-26-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Stem Cells Proton pump ATPase DNA/RNA Synthesis Antibacterial TGF-beta/Smad Inhibitor Transforming growth factor beta inhibit Proton Pump inhibitor