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BMP signaling agonist sb4

Catalog No. T7799 CAS 100874-08-6

Synonyms: SB 4

BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)

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BMP signaling agonist sb4 Chemical Structure

BMP signaling agonist sb4, CAS 100874-08-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 90.00
50 mg	In stock	$ 128.00
100 mg	In stock	$ 197.00
200 mg	In stock	$ 297.00
500 mg	In stock	$ 516.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.94%

Purity: 99.24%

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Description	BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
Targets&IC50	BMP:74 nM(EC50)
In vitro	SB4, that rapidly stimulated BMP signaling in these cells. Activation of BMP signaling by sb4 increased the phosphorylation of key second messengers (SMAD-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, Id1 and Id3) in canonical BMP signaling[1].

Synonyms	SB 4
Molecular Weight	320.2
Formula	C14H10BrNOS
CAS No.	100874-08-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (31.23 mM)

References and Literature

1. Bradford S T J , Ranghini E J , Grimley E , et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds[J]. Journal of Biological Chemistry, 2019.

Citations

1. Zhang H, Chen C, Liu Y, et al. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules. Oxidative Medicine and Cellular Longevity. 2022

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Stem Cell Differentiation Compound Library Anti-Cancer Compound Library Reprogramming Compound Library Anti-Pancreatic Cancer Compound Library Cytokine Inhibitor Library NO PAINS Compound Library Cancer Cell Differentiation Compound Library Kinase Inhibitor Library

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HALOFUGINONE LACTATE AXL-IN-13 Monocrotaline TP0427736 TGFβRI-IN-3 DT-6 LSKL, Inhibitor of Thrombospondin TSP-1 acetate SD-208

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Keywords

BMP signaling agonist sb4 100874-08-6 Stem Cells TGF-beta/Smad Inhibitor SMAD bmp cell inhibit SB4 SB-4 BRE-luc SB 4 BMP signaling agonist sb 4 Transforming growth factor beta receptors PREC BMP signaling agonist sb-4 agonist TGF-β Receptor inhibitor

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